Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma

Kuwabara, Shota; Tsuchikawa, Takahiro; Nakamura, Toru et al.

Cancer science, 2019, 110(6), 1853-1862

Permalink : https://hdl.handle.net/2115/75208

このアイテムのアクセス数:718件（2026-08-10 14:23 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
https://doi.org/10.1111/cas.14023     24

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/75208
タイトル
Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma
著者
Kuwabara, Shota ; Tsuchikawa, Takahiro ; Nakamura, Toru ; Hatanaka, Yutaka ; Hatanaka, Kanako C. ; Sasaki, Katsunori ; Ono, Masato ; Umemoto, Kazufumi ; Suzuki, Tomohiro ; Sato, Osamu ; Hane, Yuma ; Nakanishi, Yoshitsugu ; Asano, Toshimichi ; Ebihara, Yuma ; Kurashima, Yo ; Noji, Takehiro ; Murakami, Soichi ; Okamura, Keisuke ; Shichinohe, Toshiaki ; Hirano, Satoshi
著者名
Kuwabara, Shota
e-Rad_Researcher
50507572
著者名
Tsuchikawa, Takahiro
e-Rad_Researcher
70645796
著者名
Nakamura, Toru
e-Rad_Researcher
30589924
著者名
Hatanaka, Yutaka
著者名
Hatanaka, Kanako C.
e-Rad_Researcher
60336394
著者名
Sasaki, Katsunori
著者名
Ono, Masato
著者名
Umemoto, Kazufumi
著者名
Suzuki, Tomohiro
著者名
Sato, Osamu
著者名
Hane, Yuma
e-Rad_Researcher
40447058
著者名
Nakanishi, Yoshitsugu
e-Rad_Researcher
10756688
著者名
Asano, Toshimichi
e-Rad_Researcher
50632981
著者名
Ebihara, Yuma
e-Rad_Researcher
40374350
著者名
Kurashima, Yo
e-Rad_Researcher
10739296
著者名
Noji, Takehiro
e-Rad_Researcher
80706573
著者名
Murakami, Soichi
e-Rad_Researcher
90724401
著者名
Okamura, Keisuke
e-Rad_Researcher
70374353
著者名
Shichinohe, Toshiaki
e-Rad_Researcher
50322813
著者名
Hirano, Satoshi
言語
英語
キーワード
chemoradiotherapy
immunology
neoadjuvant
pancreatic cancer
tumor microenvironment
発行日
2019-06
出版者
John Wiley & Sons
収録物名
Cancer science
巻(号)
110(6)
ページ
1853-1862
抄録
The efficacy of preoperative neoadjuvant chemoradiotherapy (NAC) in cases of pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect prognoses following chemoradiotherapy using tertiary lymphoid organs (TLO) expressed in the tumor microenvironment. Resected tumor specimens were obtained from 140 pancreatic cancer patients. We retrospectively investigated the clinical relevance of TLO by categorizing patients into those who underwent upfront surgery (surgery first [SF]) and those who received NAC. The immunological elements within TLO were analyzed by immunohistochemistry (IHC). In the IHC analysis, the proportions of CD8+ T lymphocytes, PNAd+ high endothelial venules, CD163+ macrophages and Ki-67+ cells within the TLO were higher in the NAC group than in the SF group. In contrast, the proportion of programmed cell death-1+ immunosuppressive lymphocytes within TLO was lower in the NAC group than in the SF group. The NAC group demonstrated favorable prognoses compared with the SF group. In the multivariate analysis, the TLO/tumor ratio was determined as an independent predictive prognostic factor. In conclusion, the administration of preoperative chemoradiotherapy may influence the immunological elements in the tumor microenvironment and result in favorable prognoses in pancreatic ductal adenocarcinoma patients.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
1347-9032
関連情報
PMID
30997706
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1111/cas.14023