Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study

Konishi, Takao; Kashiwagi, Yusuke; Funayama, Naohiro et al.

Heart and vessels, 2019, 34(8), 1266-1279

Permalink : https://hdl.handle.net/2115/75268

このアイテムのアクセス数:645件（2026-08-10 11:14 集計）

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https://doi.org/10.1007/s00380-019-01363-8     11

論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/75268
タイトル
Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study
著者
Konishi, Takao ; Kashiwagi, Yusuke ; Funayama, Naohiro ; Yamamoto, Tadashi ; Murakami, Hironori ; Hotta, Daisuke ; Tanaka, Shinya
著者名
Konishi, Takao
著者名
Kashiwagi, Yusuke
著者名
Funayama, Naohiro
著者名
Yamamoto, Tadashi
著者名
Murakami, Hironori
著者名
Hotta, Daisuke
e-Rad_Researcher
70261287
著者名
Tanaka, Shinya
言語
英語
キーワード
Obstructive sleep apnea
Plaque instability
Optical frequency domain imaging
発行日
2019-08
出版者
Springer
収録物名
Heart and vessels
巻(号)
34(8)
ページ
1266-1279
抄録
Obstructive sleep apnea (OSA) is associated with coronary artery disease (CAD) and with an increased risk for myocardial infarction, stroke or death due to cardiovascular disease. Optical frequency-domain imaging (OFDI) is a useful modality for evaluating the characteristics of atherosclerotic plaque. The purpose of the study was to use OFDI to investigate the association of OSA with coronary plaque characteristics in patients undergoing percutaneous coronary intervention (PCI). We retrospectively analyzed OFDI data for coronary artery plaques from 15 patients with OSA and 35 non-OSA patients treated between October 2015 and October 2018. Plaque morphology was evaluated for 70 lesions, including 21 from patients with OSA and 49 from non-OSA patients. Compared with the non-OSA group, patients with OSA had significantly higher prevalences of thinned cap fibroatheroma (TCFA) (67% vs. 35%, P=0.014) and microchannels (86% vs. 55%, P=0.014); a significantly higher mean lipid index (1392 +/- 982 vs. 817 +/- 699, P=0.021), macrophage grade (8.4 +/- 6.4 vs. 4.8 +/- 4.5, P=0.030), and maximum number of microchannels (1.5 +/- 1.0 vs. 0.7 +/- 0.7, P=0.001); and a significantly lower mean minimum fibrous cap thickness (69.4 +/- 28.7 vs. 96.1 +/- 51.8 mu m, P=0.008). This OFDI analysis suggests that OSA is associated with unstable plaque characteristics in patients with CAD. More intensive medical management for stabilization of coronary atherosclerotic plaque is required in patients with OSA.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
0910-8327
EISSN
1615-2573
NCID
AA10452161
関連情報
PMID
30790035
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1007/s00380-019-01363-8