Immune-mediated antitumor effect of a transplanted lymph node

Maeda, Taku; Hayashi, Toshihiko; Furukawa, Hiroshi; Iwasaki, Daisuke; Ishikawa, Kosuke; Funayama, Emi; Murao, Naoki; Osawa, Masayuki; Oyama, Akihiko; Yamamoto, Yuhei

Immune-mediated antitumor effect of a transplanted lymph node

Maeda, Taku; Hayashi, Toshihiko; Furukawa, Hiroshi et al.

International journal of cancer, 2018, 143(5), 1224-1235

Permalink : https://hdl.handle.net/2115/75318

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/75318
タイトル	Immune-mediated antitumor effect of a transplanted lymph node
著者	Maeda, Taku ; Hayashi, Toshihiko ; Furukawa, Hiroshi ; Iwasaki, Daisuke ; Ishikawa, Kosuke ; Funayama, Emi ; Murao, Naoki ; Osawa, Masayuki ; Oyama, Akihiko ; Yamamoto, Yuhei
著者名 Maeda, Taku
著者名 Hayashi, Toshihiko
e-Rad_Researcher 00399924 著者名 Furukawa, Hiroshi
著者名 Iwasaki, Daisuke
著者名 Ishikawa, Kosuke
著者名 Funayama, Emi
e-Rad_Researcher 90706558 著者名 Murao, Naoki
著者名 Osawa, Masayuki
著者名 Oyama, Akihiko
e-Rad_Researcher 70271674 著者名 Yamamoto, Yuhei
言語	英語
キーワード	antitumor effect
	lymph node transplantation
	lymphatic system
	melanoma
	tumor-draining lymph node
発行日	2018-09-01
出版者	John Wiley & Sons
収録物名	International journal of cancer
巻(号)	143(5)
ページ	1224-1235
抄録	Lymph node (LN) transplantation is a recognized method for reconstruction of the lymphatic system and is used in the clinical setting to treat lymphedema. However, it is unclear whether transplanted LNs contribute to immune surveillance. In our study, we investigated whether a single transplanted non-vascularized LN, defined as a tumor-draining transplanted lymph node (TDTLN), could exert an immune-mediated antitumor effect. LN and lung metastases and primary tumor enlargement were evaluated in mice that were inoculated with B16-F10-luc2 melanoma cells in a hind limb footpad without (group 1) and with (group 2) popliteal lymph node (PLN) resection and in mice that underwent LN transplantation after PLN resection (group 3). The function of a TDTLN (group 3) and a tumor-draining popliteal lymph node (TDPLN; group 1) was evaluated in the context of cancer. LN and lung metastases were significantly aggravated by PLN resection but were significantly decreased by LN transplantation. Immunohistochemistry showed that the TDTLNs retained T-cells and B-cells and fluorescence-activated cell sorting analysis confirmed expansion of lymphocytes in these nodes; however, the degree of expansion in TDTLNs was different from that in TDPLNs. Expression of cytokines associated with immunostimulation was confirmed in the TDTLNs as well as in the TDPLNs. One of the differences in the immune-mediated antitumor effect of the TDPLNs and TDTLNs was ascribed to a difference in the site of lymphocyte homing to peripheral LNs through high endothelial venules. Non-vascularized LN transplantation had an immune-mediated antitumor effect.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Maeda, T., Hayashi, T., Furukawa, H. Iwasaki, D., Ishikawa, K., Funayama, E., Murao, N., Osawa, M., Oyama, A. and Yamamoto, Y. (2018), Immune‐mediated antitumor effect of a transplanted lymph node. Int. J. Cancer, 143: 1224-1235., which has been published in final form at https://doi.org/10.1002/ijc.31414. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
PISSN	0020-7136
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/ijc.31414