Differences in interleukin-1β release-inducing activity of Candida albicans toward dendritic cells and macrophages.

Hasebe, A; Saeki, A; Yoshida, Y; Shibata, KI

Differences in interleukin-1β release-inducing activity of Candida albicans toward dendritic cells and macrophages.

Hasebe, A; Saeki, A; Yoshida, Y et al.

Archives of oral biology, 2018, 93, 115-125

Permalink : https://hdl.handle.net/2115/75324

このアイテムのアクセス数:734件（2026-08-18 06:34 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
AOB Revise2	pdf	2.52 MB	708

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/75324
タイトル	Differences in interleukin-1β release-inducing activity of Candida albicans toward dendritic cells and macrophages.
著者	Hasebe, A ; Saeki, A ; Yoshida, Y ; Shibata, KI
e-Rad_Researcher 90281815 著者名 Hasebe, A
e-Rad_Researcher 70638345 著者名 Saeki, A
e-Rad_Researcher 90281162 著者名 Yoshida, Y
e-Rad_Researcher 50145265 著者名 Shibata, KI
言語	英語
キーワード	Interleukin-1β
	Candida albicans
	Dendritic cells
	Macrophages
発行日	2018-09
収録物名	Archives of oral biology
巻(号)	93
ページ	115-125
抄録	Objective: The purpose of this study is to elucidate differences in the mechanism of the IL-1β release-inducing activity of Candida albicans toward dendritic cells and macrophages because IL-1β is one of the proinflammatory cytokines which is crucial in host defense against candidiasis.Design: Two C. albicans strains were used in this study. One strain is uridineauxotrophic (CAI4) that needs uridine to grow and form hyphae, and another is a strain without any specific auxotrophy (pACT1-GFP), which forms hyphae naturally by culturing with serum components. Murine macrophage and dendritic cell lines were primed with LPS and then stimulated with C. albicans CAI4 or pACT1-GFP. Results: Both strains of C. albicans induced IL-1β release from dendritic cells, and C. albicans pACT1-GFP induced IL-1β release but CAI4 induced little amounts in macrophages. These differences were suggested to be due to the difference in the amount of extracellular ATP released in the cell culture supernatants induced by C. albicans CAI4 or pACT1-GFP. For induction of IL-1β release from both macrophages and dendritic cells by C. albicans, direct contacts of the microbes with cells were required. In addition, macrophages required morphological change of C. albicans from yeast to hyphae for induction of IL-1β release, whereas dendritic cells did not require it. Dead C. albicans could induce IL-1β release from dendritic cells, but could not from macrophages. Conclusions: There are different mechanisms by which C. albicans induces IL-1β release from dendritic cells and macrophages.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© <2018>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0003-9969
EISSN	1879-1506
NCID	AA00548457
関連情報	PMID 29894908
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.archoralbio.2018.06.004