Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs

Khadiza, Naznin; Hasegawa, Tomoka; Nagai, Tomoya; Yamamoto, Tomomaya; Miyamoto-Takasaki, Yukina; Hongo, Hiromi; Abe, Miki; Haraguchi, Mai; Yamamoto, Tsuneyuki; Yi, Min; Qiu, Zixuan; Sasaki, Muneteru; Kuroshima, Shinichiro; Ohshima, Hayato; Luiz de Freitas, Paulo Henrique; Li, Minqi; Yawaka, Yasutaka; Amizuka, Norio

Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs

Khadiza, Naznin; Hasegawa, Tomoka; Nagai, Tomoya et al.

Biomedical Research (Tokyo), 2019, 40(4), 133-143

Permalink : https://hdl.handle.net/2115/75445

このアイテムのアクセス数:755件（2026-04-05 13:31 集計）

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https://doi.org/10.2220/biomedres.40.133			3

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/75445
タイトル	Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs
著者	Khadiza, Naznin ; Hasegawa, Tomoka ; Nagai, Tomoya ; Yamamoto, Tomomaya ; Miyamoto-Takasaki, Yukina ; Hongo, Hiromi ; Abe, Miki ; Haraguchi, Mai ; Yamamoto, Tsuneyuki ; Yi, Min ; Qiu, Zixuan ; Sasaki, Muneteru ; Kuroshima, Shinichiro ; Ohshima, Hayato ; Luiz de Freitas, Paulo Henrique ; Li, Minqi ; Yawaka, Yasutaka ; Amizuka, Norio
著者名 Khadiza, Naznin
e-Rad_Researcher 50739349 著者名 Hasegawa, Tomoka
著者名 Nagai, Tomoya
著者名 Yamamoto, Tomomaya
著者名 Miyamoto-Takasaki, Yukina
e-Rad_Researcher 00778970 著者名 Hongo, Hiromi
著者名 Abe, Miki
著者名 Haraguchi, Mai
e-Rad_Researcher 80200822 著者名 Yamamoto, Tsuneyuki
e-Rad_Researcher 40292007 著者名 Yi, Min
著者名 Qiu, Zixuan
著者名 Sasaki, Muneteru
著者名 Kuroshima, Shinichiro
著者名 Ohshima, Hayato
著者名 Luiz de Freitas, Paulo Henrique
著者名 Li, Minqi
e-Rad_Researcher 60230603 著者名 Yawaka, Yasutaka
e-Rad_Researcher 30242431 著者名 Amizuka, Norio
言語	英語
発行日	2019-08-01
出版者	Biomedical Research Press
収録物名	Biomedical Research (Tokyo)
巻(号)	40(4)
ページ	133-143
抄録	In this study, we attempted to localize the immunoreactivities of podoplanin/E11/gp38 and CD44, a counterpart possessing a high affinity to podoplanin/E11/gp38, as well as endomucin-immunoreactive blood vessels in the regions of odontoblast layers and the underlying sub-odontoblastic layers in murine tooth germs. Endomucin-reactive small blood vessels were scattered throughout the dental papillae of the tooth germs at postnatal day 1 but came to be localized close to the odontoblast/sub-odontoblastic layers until day 3. After postnatal day 5, small blood vessels were seen in odontoblast cell layers, while blood vessels with relatively larger diameters were seen forming in sub-odontoblastic layers. Immunoreactivities of podoplanin/E11/gp38 and CD44 were not detectable in the cells of dental papillae facing the inner enamel epithelium at postnatal day 1. However, at around postnatal days 3-5, podoplanin/E11/gp38 was localized in the odontoblast layer but not in the sub-odontoblastic layer, whereas CD44 was observed in the sub-odontoblastic layer but not in the odontoblast layer. The exclusive immunolocalization of podoplanin/E11/gp38 and CD44 in the odontoblast layers and sub-odontoblastic layers was seen after postnatal day 3 of the tooth germs, when the mesenchymal cells of dental papillae have already differentiated into mature odontoblasts at the cusp tip. Taken together, it seems likely that endomucin-reactive small blood vessels extended to the podoplanin/E11/gp38-positive odontoblast layers, whereas endomucin-reactive large blood vessels were already present in CD44-immmunopositive sub-odontoblastic layer, indicating the cellular regulation on the vascularization of endomucin-reactive endothelial cells during odontogenesis of the tooth germs.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0388-6107
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2220/biomedres.40.133