Cellular calcification induced by inorganic polyphosphate involves ATP depletion and opening of the mitochondrial permeability transition pore (mPTP)

Tsutsumi, Kaori; Sasase, Tatsuya

Febs open bio, 2019, 9(9), 1617-1622

Permalink : https://hdl.handle.net/2115/75469

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https://doi.org/10.1002/2211-5463.12703     34

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アクセス権
open access
URI
https://hdl.handle.net/2115/75469
タイトル
Cellular calcification induced by inorganic polyphosphate involves ATP depletion and opening of the mitochondrial permeability transition pore (mPTP)
著者
e-Rad_Researcher
80344505
著者名
Tsutsumi, Kaori
著者名
Sasase, Tatsuya
言語
英語
キーワード
adenosine triphosphate
calcification
inorganic polyphosphate
mitochondria
mitochondrial permeability transition pore
発行日
2019-07-20
出版者
John Wiley & Sons
収録物名
Febs open bio
巻(号)
9(9)
ページ
1617-1622
抄録
Inorganic polyphosphate (polyP) is a linear polymer containing tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. PolyP promotes osteocalcification and bone mineralization in both mouse and human osteoblastic cells. In the present study, we examined the molecular mechanism by which polyP affects mitochondrial metabolism to promote cellular calcification in MC3T3-E1 osteoblastic cells. The cellular content of adenosine triphosphate (ATP) was diminished one day after polyP treatment, and this was accompanied by increased conversion to adenosine diphosphate. Furthermore, mitochondrial membrane potential was significantly decreased in polyP-treated cells. These results suggest that the depletion of intracellular ATP and the decrease in mitochondrial membrane potential induced by polyP treatment may be a trigger to promote cell calcification.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
2211-5463
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1002/2211-5463.12703