Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan

Mizumoto, Masashi; Murayama, Shigeyuki; Akimoto, Tetsuo; Demizu, Yusuke; Fukushima, Takashi; Ishida, Yuji; Oshiro, Yoshiko; Numajiri, Haruko; Fuji, Hiroshi; Okumura, Toshiyuki; Shirato, Hiroki; Sakurai, Hideyuki

Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan

Mizumoto, Masashi; Murayama, Shigeyuki; Akimoto, Tetsuo et al.

Cancer medicine, 2016, 5(7), 1519-1525

Permalink : https://hdl.handle.net/2115/75511

このアイテムのアクセス数:593件（2026-04-06 18:50 集計）

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https://doi.org/10.1002/cam4.743			12

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/75511
タイトル	Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan
著者	Mizumoto, Masashi ; Murayama, Shigeyuki ; Akimoto, Tetsuo ; Demizu, Yusuke ; Fukushima, Takashi ; Ishida, Yuji ; Oshiro, Yoshiko ; Numajiri, Haruko ; Fuji, Hiroshi ; Okumura, Toshiyuki ; Shirato, Hiroki ; Sakurai, Hideyuki
e-Rad_Researcher 20512388 著者名 Mizumoto, Masashi
e-Rad_Researcher 60231635 著者名 Murayama, Shigeyuki
e-Rad_Researcher 10261851 著者名 Akimoto, Tetsuo
著者名 Demizu, Yusuke
著者名 Fukushima, Takashi
著者名 Ishida, Yuji
e-Rad_Researcher 50550159 著者名 Oshiro, Yoshiko
e-Rad_Researcher 00712845 著者名 Numajiri, Haruko
e-Rad_Researcher 70426435 著者名 Fuji, Hiroshi
e-Rad_Researcher 50241815 著者名 Okumura, Toshiyuki
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
e-Rad_Researcher 50235222 著者名 Sakurai, Hideyuki
言語	英語
キーワード	Observational study
	PBT
	Pediatric
	Proton beam therapy
	Radiotherapy
発行日	2016-07
出版者	Wiley
収録物名	Cancer medicine
巻(号)	5(7)
ページ	1519-1525
抄録	Recent progress in the treatment for pediatric malignancies using a combination of surgery, chemotherapy, and radiotherapy has improved survival. However, late toxicities of radiotherapy are a concern in long‐term survivors. A recent study suggested reduced secondary cancer and other late toxicities after proton beam therapy (PBT) due to dosimetric advantages. In this study, we evaluated the safety and efficacy of PBT for pediatric patients treated in Japan. A retrospective observational study in pediatric patients who received PBT was performed. All patients aged <20 years old who underwent PBT from January 1983 to August 2014 at four sites in Japan were enrolled in the study. There were 343 patients in the study. The median follow‐up periods were 22.6 months (0.4–374.3 months) for all patients and 30.6 months (0.6–374.3 months) for survivors. The estimated 1‐, 3‐, 5‐, and 10‐year survival rates were 82.7% (95% CI: 78.5–87.0%), 67.4% (61.7–73.2%), 61.4% (54.8–67.9%), and 58.7% (51.5–65.9%), respectively. Fifty‐two events of toxicity ≥ grade 2 occurred in 43 patients. Grade 4 toxicities of myelitis, visual loss (two cases), cerebral vascular disease, and tissue necrosis occurred in five patients. This study provides preliminary results for PBT in pediatric patients in Japan. More experience and follow‐up with this technique are required to establish the efficacy of PBT in this patient population.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
EISSN	2045-7634
関連情報	PMID 27165972
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1002/cam4.743