Anti-mumps IgM antibody positive rate with sudden sensorineural hearing loss using second-generation enzyme immunoassay : A retrospective, multi-institutional investigation in Hokkaido, Japan

Fukuda, Atsushi; Morita, Shinya; Nakamaru, Yuji; Hoshino, Kimiko; Fujiwara, Keishi; Akazawa, Shigeru; Sakashita, Tomohiro; Obara, Nobuyuki; Homma, Akihiro

Anti-mumps IgM antibody positive rate with sudden sensorineural hearing loss using second-generation enzyme immunoassay : A retrospective, multi-institutional investigation in Hokkaido, Japan

Fukuda, Atsushi; Morita, Shinya; Nakamaru, Yuji et al.

Auris nasus larynx, 2018, 45(5), 911-915

Permalink : https://hdl.handle.net/2115/75597

このアイテムのアクセス数:770件（2026-08-17 20:20 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
AurisNasusLarynx45_911	pdf	394 KB	608

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/75597
タイトル	Anti-mumps IgM antibody positive rate with sudden sensorineural hearing loss using second-generation enzyme immunoassay : A retrospective, multi-institutional investigation in Hokkaido, Japan
著者	Fukuda, Atsushi ; Morita, Shinya ; Nakamaru, Yuji ; Hoshino, Kimiko ; Fujiwara, Keishi ; Akazawa, Shigeru ; Sakashita, Tomohiro ; Obara, Nobuyuki ; Homma, Akihiro
著者名 Fukuda, Atsushi
著者名 Morita, Shinya
e-Rad_Researcher 20344509 著者名 Nakamaru, Yuji
著者名 Hoshino, Kimiko
著者名 Fujiwara, Keishi
著者名 Akazawa, Shigeru
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
著者名 Obara, Nobuyuki
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
言語	英語
キーワード	Mumps deafness
	Asymptomatic mumps
	Anti-mumps IgM antibody
	Sudden sensorineural hearing loss (SSNHL)
	Vaccination
発行日	2018-10
出版者	Elsevier
収録物名	Auris nasus larynx
巻(号)	45(5)
ページ	911-915
抄録	Objective: Although elevated anti-mumps IgM antibody levels were reported in 5.7%-7.2% of Japanese patients with sudden sensorineural hearing loss (SSNHL), there were several reports of false-positive cases, such as the continually IgM positive case and the IgM positive case in normal adults. To improve specificity, the new enzyme immuno assay (EIA) anti-mumps IgM antibody measurement kit was introduced in December 2009. This study re-examined the frequency of anti mumps IgM antibody test positivity with SSNHL using the new measurement kit and compared the results with those from a previous report that used old kit. Methods: This is a retrospective multi-institutional study involving patients diagnosed with SSNHL who exhibited the anti-mumps IgM antibody. We compared the positive rate of anti-mumps IgM antibody and the annual average number of mumps cases per sentinel in Hokkaido between the patients in the present study and patients previously evaluated. Results: Overall, 100 patients with SSNHL were enrolled. One case (1.0%) was positive for anti mumps IgM antibody. Of the 69 patients evaluated in the previous study, 5 cases (7.2%) were positive for anti-mumps IgM antibody. The positive rate of the anti-mumps IgM antibody in the present cases was significantly lower than that previously reported (p = 0.042). The annual average number of mumps cases per sentinel in Hokkaido of the present and previous surveillance period was 34.47 and 42.77, respectively; no significant difference was seen in these data (p = 0.4519). Conclusion: The present study revealed that 1.0% of SSNHL was positive for the anti-mumps IgM antibody using the new EIA-IgM measurement kit. After the introduction of the new EIA-IgM measurement kit, anti-mumps IgM antibody positive rate with SSNHL significantly decreased, indicating that the proportion of asymptomatic mumps among etiology of SSNHL may be lower than those previously reported.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0385-8146
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.anl.2017.11.016