Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2 : temperance reduces the risk

Abiko, Satoshi; Shimizu, Yuichi; Miyamoto, Shuichi et al.

Journal of gastroenterology, 2018, 53(10), 1120-1130

Permalink : https://hdl.handle.net/2115/75623

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アクセス権
open access
URI
https://hdl.handle.net/2115/75623
タイトル
Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2 : temperance reduces the risk
その他のタイトル
Risk of metachronous SCC
著者
Abiko, Satoshi ; Shimizu, Yuichi ; Miyamoto, Shuichi ; Ishikawa, Marin ; Matsuda, Kana ; Tsuda, Momoko ; Mizushima, Takeshi ; Yamamoto, Keiko ; Ono, Shoko ; Kudo, Takahiko ; Ono, Kota ; Sakamoto, Naoya
著者名
Abiko, Satoshi
e-Rad_Researcher
90333608
著者名
Shimizu, Yuichi
著者名
Miyamoto, Shuichi
著者名
Ishikawa, Marin
著者名
Matsuda, Kana
著者名
Tsuda, Momoko
著者名
Mizushima, Takeshi
著者名
Yamamoto, Keiko
著者名
Ono, Shoko
著者名
Kudo, Takahiko
著者名
Ono, Kota
e-Rad_Researcher
10334418
著者名
Sakamoto, Naoya
言語
英語
キーワード
Alcohol dehydrogenase1B
Aldehyde dehydrogenase2
Squamous cell carcinoma
Esophageal cancer
Endoscopic resection
発行日
2018-10
出版者
Springer
収録物名
Journal of gastroenterology
巻(号)
53(10)
ページ
1120-1130
抄録
Background: Metachronous multiple squamous cell carcinoma (SCC) of the esophagus and the head and neck is commonly observed in patients who have previously undergone endoscopic resection (ER) for SCC of the esophagus (ESCC). We evaluated the risk for developing metachronous SCC following ER for ESCC based on the genetic polymorphisms for alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) as well as the alcohol consumption and smoking habits. Methods: We studied 158 patients who underwent ER for ESCC (median follow-up 80 months). Genotyping of ADH1B/ALDH2 was performed using saliva sampling. The alcohol consumption and smoking histories of the patients before and after the ER were documented. Results: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC. We analyzed 110 patients who had a history of moderate or heavy alcohol consumption before the ER. The 3-year cumulative incidence rates of secondary SCC in the temperance (n = 65) and non-temperance groups (n = 45) were 14.0 and 42.1% (p = 0.0002). Further, the 5-year cumulative incidence rates of a third SCC in the temperance and non-temperance groups were 0 and 15.6% (p = 0.0011), respectively. In addition, the 7-year cumulative incidence rates of a fourth SCC in the temperance and non-temperance groups were 0 and 15.3% (p = 0.0015), respectively. Conclusions: Continued alcohol consumption is an important risk factor for the onset of metachronous SCC and is a risk factor for the third and subsequent SCCs. Strict advice in favor of temperance is crucial.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The final publication is available at link.springer.com
PISSN
0944-1174
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s00535-018-1441-7