open access

https://hdl.handle.net/2115/75815

食餌による 12 α 水酸化胆汁酸代謝の調節を介する脂肪肝の予防 ： オリゴ糖および乳製品を用いたラットにおける研究 [全文の要約]

英語

2019-09-25

Hokkaido University

https://www.lib.hokudai.ac.jp/dissertations/copy-guides/

There is a growing concern about fatty liver worldwide. Excessive energy consumption increases biosynthesis of fatty acid or sterols in the liver. In this condition, biosynthesis of 12α-hydroxylated bile acids (12αOH-BAs) is also enhanced in the liver. Such alteration of BA metabolism is successfully mimicked in rats by a supplementation of cholic acid (CA) to diet, without any change in the proportion of lipids or carbohydrate contents in the diet. Moreover, the CA diet induces lipid accumulation or leaky gut. Some studies have already shown that oligosaccharides or dairy products mitigate lipid metabolism, but such preventive effects seem diverse depending on those types and almost no information is available not only in BA metabolism but also the mechanisms underlying. The purpose of the study is to investigate relationship between lipid metabolism include in those dietary interventions.

甲第13761号

博士(農学)

(主査) 教授 石塚 敏, 教授 園山 慶, 教授 玖村 朗人

農学院（応用生物科学専攻）

博士論文

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