Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese　: the Japan Collaborative Cohort Study

Nishida, Yoko; Kubota, Yasuhiko; Iso, Hiroyasu et al.

Journal of atherosclerosis and thrombosis, 2019, 26(9), 775-782

Permalink : https://hdl.handle.net/2115/75845

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https://doi.org/10.5551/jat.46383     8

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アクセス権
open access
URI
https://hdl.handle.net/2115/75845
タイトル
Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese　: the Japan Collaborative Cohort Study
著者
Nishida, Yoko ; Kubota, Yasuhiko ; Iso, Hiroyasu ; Tamakoshi, Akiko ; Mori, Mitsuru ; Kaneko, Yoshihiro ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Yamagishi, Kazumasa ; Mikami, Haruo ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Tamakoshi, Koji ; Wakai, Kenji ; Ando, Masahiko ; Suzuki, Koji ; Hashimoto, Shuji ; Yatsuya, Hiroshi ; Kikuchi, Shogo ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Mikami, Kazuya ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Fujino, Yoshihisa ; Shibata, Akira
著者名
Nishida, Yoko
著者名
Kubota, Yasuhiko
e-Rad_Researcher
50223053
著者名
Iso, Hiroyasu
e-Rad_Researcher
90236737
著者名
Tamakoshi, Akiko
著者名
Mori, Mitsuru
著者名
Kaneko, Yoshihiro
著者名
Tsuji, Ichiro
著者名
Nakamura, Yosikazu
著者名
Iso, Hiroyasu
著者名
Yamagishi, Kazumasa
著者名
Mikami, Haruo
著者名
Kurosawa, Michiko
著者名
Hoshiyama, Yoshiharu
著者名
Tanabe, Naohito
著者名
Tamakoshi, Koji
著者名
Wakai, Kenji
著者名
Ando, Masahiko
著者名
Suzuki, Koji
著者名
Hashimoto, Shuji
著者名
Yatsuya, Hiroshi
著者名
Kikuchi, Shogo
著者名
Wada, Yasuhiko
著者名
Kawamura, Takashi
著者名
Watanabe, Yoshiyuki
著者名
Ozasa, Kotaro
著者名
Mikami, Kazuya
著者名
Date, Chigusa
著者名
Sakata, Kiyomi
著者名
Kurozawa, Yoichi
著者名
Fujino, Yoshihisa
著者名
Shibata, Akira
言語
英語
キーワード
Eczema
Cardiovascular disease
Atherosclerosis
CHD
Population-based study
発行日
2019-09-01
出版者
Japan Atherosclerosis Society (JAS)
日本動脈硬化学会
収録物名
Journal of atherosclerosis and thrombosis
巻(号)
26(9)
ページ
775-782
抄録
Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial. Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Results: During the 6,389,818 person-years of follow-up, there were 1,174 deaths from coronary heart disease (CHD), 979 from heart failure, 366 from cardiac arrhythmia, 2,454 from total stroke, 1,357 from ischemic stroke, 1,013 from hemorrhagic stroke, and 201 from aortic aneurysm or dissection. The multivariable-adjusted model showed that individuals who "sometimes" or "often" had eczema had 0.82 (95%confidence interval (CI): 0.69-0.97) or 1.26 (95%CI: 1.01-1.56) times the risk of mortality from CHD, respectively, compared to those who "seldom" did. Individuals who "often" had 1.30 (95%CI: 1.05-1.61) times the risk of mortality from CHD, compared to those who "seldom or sometimes" did. There was no association of eczema with mortality from other CVD, or no interaction between eczema and sex or age, in relation to any CVD mortality risk. Conclusions: Self-reported frequent eczema was associated with increased risk of mortality from CHD, but not other major CVD, in a Japanese general population. Since steroid usage was not considered, future studies should include it as a potential confounding factor.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
PISSN
1340-3478
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.5551/jat.46383