Evaluation of duodenal perfusion by contrast-enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma

Nisa, Khoirun; Lim, Sue Yee; Shinohara, Masayoshi; Osuga, Tatsuyuki; Yokoyama, Nozomu; Tamura, Masahiro; Nagata, Noriyuki; Sasaoka, Kazuyoshi; Dermlim, Angkhana; Leela-Arporn, Rommaneeya; Morita, Tomoya; Sasaki, Noboru; Morishita, Keitaro; Nakamura, Kensuke; Ohta, Hiroshi; Takiguchi, Mitsuyoshi

Evaluation of duodenal perfusion by contrast-enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma

Nisa, Khoirun; Lim, Sue Yee; Shinohara, Masayoshi et al.

Journal of Veterinary Internal Medicine, 2019, 33(2), 559-568

Permalink : https://hdl.handle.net/2115/75895

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アクセス権	open access
URI	https://hdl.handle.net/2115/75895
タイトル	Evaluation of duodenal perfusion by contrast-enhanced ultrasonography in dogs with chronic inflammatory enteropathy and intestinal lymphoma
著者	Nisa, Khoirun ; Lim, Sue Yee ; Shinohara, Masayoshi ; Osuga, Tatsuyuki ; Yokoyama, Nozomu ; Tamura, Masahiro ; Nagata, Noriyuki ; Sasaoka, Kazuyoshi ; Dermlim, Angkhana ; Leela-Arporn, Rommaneeya ; Morita, Tomoya ; Sasaki, Noboru ; Morishita, Keitaro ; Nakamura, Kensuke ; Ohta, Hiroshi ; Takiguchi, Mitsuyoshi
著者名 Nisa, Khoirun
著者名 Lim, Sue Yee
著者名 Shinohara, Masayoshi
著者名 Osuga, Tatsuyuki
著者名 Yokoyama, Nozomu
著者名 Tamura, Masahiro
著者名 Nagata, Noriyuki
著者名 Sasaoka, Kazuyoshi
著者名 Dermlim, Angkhana
著者名 Leela-Arporn, Rommaneeya
著者名 Morita, Tomoya
e-Rad_Researcher 00754532 著者名 Sasaki, Noboru
e-Rad_Researcher 30637046 著者名 Morishita, Keitaro
e-Rad_Researcher 80625898 著者名 Nakamura, Kensuke
e-Rad_Researcher 50431333 著者名 Ohta, Hiroshi
e-Rad_Researcher 70261336 著者名 Takiguchi, Mitsuyoshi
言語	英語
キーワード	CEUS
	enhancement
	intestinal diseases
	tissue perfusion
発行日	2019-03
出版者	John Wiley & Sons
収録物名	Journal of Veterinary Internal Medicine
巻(号)	33(2)
ページ	559-568
抄録	Background: Contrast-enhanced ultrasonography (CEUS) can be used to evaluate intestinal perfusion in healthy dogs. It is helpful for diagnosing and monitoring inflammatory bowel disease in humans and could be useful for dogs with chronic intestinal diseases. Objectives: To examine duodenal perfusion in dogs with chronic inflammatory enteropathy (CIE) and intestinal lymphoma. Animals: Client-owned dogs with CIE (n = 26) or intestinal lymphoma (n = 7) and dogs with gastrointestinal signs but histopathologically normal duodenum (controls, n = 14). Methods: In this cross-sectional study, clogs with CIE were classified into remission (n = 16) and symptomatic (n = 10) groups based on clinical scores determined at the time of CEUS. The duodenum was scanned after IV injection of Sonazoid (R) (0.01 mL/kg). CEUS-derived perfusion parameters, including time-to-peak, peak intensity (PI), area under the curve (AUC), and wash-in and wash-out rates were evaluated. Results: The PI was significantly higher in the symptomatic CIE group (median (range); 105.4 (89.3-128.8) MPV) than in the control group (89.9 (68.5-112.2) MPV). The AUC was significantly higher in the symptomatic CIE group (4847.9 (3824.3-8462.8) MPV.sec) than in the control (3448.9 (1559.5-4736.9) MPV.sec) and remission CIE (3862.3 (2094.5-6899.0) MPV.sec) groups. The PI and clinical score were positively correlated in the CIE group. No significant differences in perfusion parameters were detected between the lymphoma and CIE groups or the lymphoma and control groups. Conclusions and Clinical Importance: The PI and AUC can detect duodenal inflammation and hence are potentially useful for excluding a diagnosis of CIE.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	0891-6640
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/jvim.15432