Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia : A Hokkaido Leukemia Net Study

Hidaka, Daisuke; Onozawa, Masahiro; Hashiguchi, Junichi; Miyashita, Naohiro; Kasahara, Kohei; Fujisawa, Shinichi; Hayase, Eiko; Okada, Kohei; Shiratori, Souichi; Goto, Hideki; Sugita, Junichi; Nakagawa, Masao; Hashimoto, Daigo; Kahata, Kaoru; Endo, Tomoyuki; Yamamoto, Satoshi; Tsutsumi, Yutaka; Haseyama, Yoshihito; Nagashima, Takahiro; Mori, Akio; Ota, Shuichi; Sakai, Hajime; Ishihara, Toshimichi; Imai, Kiyotoshi; Miyagishima, Takuto; Kakinoki, Yasutaka; Kurosawa, Mitsutoshi; Kobayashi, Hajime; Iwasaki, Hiroshi; Shimizu, Chikara; Kondo, Takeshi; Teshima, Takanori

Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia : A Hokkaido Leukemia Net Study

Hidaka, Daisuke; Onozawa, Masahiro; Hashiguchi, Junichi et al.

Clinical Lymphoma, Myeloma and Leukemia, 2018, 18(11), e469-e479

Permalink : https://hdl.handle.net/2115/75971

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アクセス権	open access
URI	https://hdl.handle.net/2115/75971
タイトル	Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia : A Hokkaido Leukemia Net Study
著者	Hidaka, Daisuke ; Onozawa, Masahiro ; Hashiguchi, Junichi ; Miyashita, Naohiro ; Kasahara, Kohei ; Fujisawa, Shinichi ; Hayase, Eiko ; Okada, Kohei ; Shiratori, Souichi ; Goto, Hideki ; Sugita, Junichi ; Nakagawa, Masao ; Hashimoto, Daigo ; Kahata, Kaoru ; Endo, Tomoyuki ; Yamamoto, Satoshi ; Tsutsumi, Yutaka ; Haseyama, Yoshihito ; Nagashima, Takahiro ; Mori, Akio ; Ota, Shuichi ; Sakai, Hajime ; Ishihara, Toshimichi ; Imai, Kiyotoshi ; Miyagishima, Takuto ; Kakinoki, Yasutaka ; Kurosawa, Mitsutoshi ; Kobayashi, Hajime ; Iwasaki, Hiroshi ; Shimizu, Chikara ; Kondo, Takeshi ; Teshima, Takanori
著者名 Hidaka, Daisuke
e-Rad_Researcher 70455632 著者名 Onozawa, Masahiro
著者名 Hashiguchi, Junichi
著者名 Miyashita, Naohiro
著者名 Kasahara, Kohei
著者名 Fujisawa, Shinichi
著者名 Hayase, Eiko
著者名 Okada, Kohei
e-Rad_Researcher 00645905 著者名 Shiratori, Souichi
著者名 Goto, Hideki
著者名 Sugita, Junichi
著者名 Nakagawa, Masao
著者名 Hashimoto, Daigo
著者名 Kahata, Kaoru
著者名 Endo, Tomoyuki
著者名 Yamamoto, Satoshi
著者名 Tsutsumi, Yutaka
著者名 Haseyama, Yoshihito
著者名 Nagashima, Takahiro
著者名 Mori, Akio
著者名 Ota, Shuichi
著者名 Sakai, Hajime
著者名 Ishihara, Toshimichi
著者名 Imai, Kiyotoshi
著者名 Miyagishima, Takuto
著者名 Kakinoki, Yasutaka
著者名 Kurosawa, Mitsutoshi
著者名 Kobayashi, Hajime
著者名 Iwasaki, Hiroshi
e-Rad_Researcher 00292029 著者名 Shimizu, Chikara
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
キーワード	WT1
	prognostic stratification
	AML
	Hokkaido Leukemia Net (HLN)
	North Japan Hematology Study Group (NJHSG)
	SNP
発行日	2018-11
出版者	Elsevier
収録物名	Clinical Lymphoma, Myeloma and Leukemia
巻(号)	18(11)
ページ	e469-e479
抄録	The association between Wilms tumor 1 (WT1) expression, genetic abnormalities and homozygous single polymorphism (SNP) in WT1 gene was evaluated in 252 acute myelogenous leukemia (AML) patients. WT1 expression correlated with prognostic genetic abnormalities. Homozygous WT1 SNP rs16754 was associated with lower expression of WT1. WT1 expression had no prognostic impact in any cytogenetic group or SNP status. Background: The prognostic impact of WT1 expression at diagnosis of acute myelogenous leukemia (AML) has been controversial. The aim of this study was to determine the correlations of WT1 expression at diagnosis of AML with established prognostic alterations. Patients and Methods: We analyzed diagnostic bone marrow samples from 252 patients. WT1 expression, SNP in WT1 gene (rs16754), and Flt3-ITD mutation were analyzed for all patients. NPM1 mutation and CEBPA double mutation were analyzed for cytogenetically normal (CN)-AML. KIT mutation was analyzed for core-binding factor (CBF)-AML. Results: Within the cytogenetically favorable prognosis group, WT1 expression in AML with inv(16) or t(15;17) was significantly higher than that in AML with t(8;21). In cases with CN-AML, Flt3-ITD and NPM1 mutations were both correlated with higher expression of WT1, whereas CEBPA double mutation was related to lower WT1 expression. The existence of both Flt3- ITD and NPM1 mutations showed synergistically higher expression of WT1 in CN-AML. SNP in WT1 gene (rs16754) was significantly associated with lower expression of WT1. WT1 levels were not prognostic factors in the total cohort, in any cytogenetic group nor SNP status. Conclusion: Since WT1 expression correlated to known prognostic factors, the prognostic impact of WT1 levels might be misunderstood depending on the distribution of collaborative mutations in each cohort. We conclude that the prognostic significance of WT1 at diagnosis of AML is weak compared to other established prognostic factors.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	2152-2650
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.clml.2018.07.291