Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children : Sapporo cohort study

Nakajima, Sonomi; Saijo, Yasuaki; Miyashita, Chihiro; Ikeno, Tamiko; Sasaki, Seiko; Kajiwara, Junboku; Kishi, Reiko

Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children : Sapporo cohort study

Nakajima, Sonomi; Saijo, Yasuaki; Miyashita, Chihiro et al.

Environmental Research, 2017, 159, 222-231

Permalink : https://hdl.handle.net/2115/75972

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アクセス権	open access
URI	https://hdl.handle.net/2115/75972
タイトル	Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children : Sapporo cohort study
著者	Nakajima, Sonomi ; Saijo, Yasuaki ; Miyashita, Chihiro ; Ikeno, Tamiko ; Sasaki, Seiko ; Kajiwara, Junboku ; Kishi, Reiko
著者名 Nakajima, Sonomi
e-Rad_Researcher 70360906 著者名 Saijo, Yasuaki
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 80569715 著者名 Ikeno, Tamiko
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
著者名 Kajiwara, Junboku
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	dioxin-like compounds
	child development
	prenatal exposure
	background-level
	sex-specific differences
発行日	2017-11
出版者	Elsevier
収録物名	Environmental Research
巻(号)	159
ページ	222-231
抄録	BACKGROUND: Consistent reports are not available on the effects of dioxin-like polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDD)/ polychlorinated dibenzofurans (PCDF) (dioxin-like compounds [DLCs]) on child neurodevelopment. Further, the effect of background-level exposure to individual DLC isomers is not known. OBJECTIVES: We carried out the Sapporo cohort study to evaluate the effect of prenatal exposure to each DLC isomer on child neurodevelopment at 6 and 18 months of age, and assessed sex-specific differences in these effects. METHODS: The levels of all and each individual DLC isomers were estimated in maternal peripheral blood. Neurodevelopment was evaluated using the Bayley Scales of Infant Development-2nd Edition for 6-month-old infants (n = 190) and 18-month-old children (n = 121). RESULTS: In male children, levels of 10 DLC isomers were significantly negatively associated with the Psychomotor Developmental Index (PDI) at 6 months of age after adjustment for potential confounding variables. However, at 18 months of age, these associations were absent. In female children, the level of only one DLC isomer was significantly negatively associated with PDI at 6 months of age. However, in contrast to the male children, the levels of six DLC isomers in 18-month-old female children were significantly positively associated with the Mental Developmental Index. CONCLUSIONS: These findings indicate that adverse neurodevelopmental effects of prenatal background-level exposure to DLCs may be stronger in male children.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0013-9351
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.envres.2017.08.006