EPR-based oximetric imaging : a combination of single point-based spatial encoding and T1 weighting

Matsumoto, Ken-ichiro; Kishimoto, Shun; Devasahayam, Nallathamby; Chandramouli, Gadisetti V. R.; Ogawa, Yukihiro; Matsumoto, Shingo; Krishna, Murali C.; Subramanian, Sankaran

EPR-based oximetric imaging : a combination of single point-based spatial encoding and T1 weighting

Matsumoto, Ken-ichiro; Kishimoto, Shun; Devasahayam, Nallathamby et al.

Magnetic Resonance in Medicine, 2018, 80(5), 2275-2287

Permalink : https://hdl.handle.net/2115/76009

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/76009
タイトル	EPR-based oximetric imaging : a combination of single point-based spatial encoding and T1 weighting
著者	Matsumoto, Ken-ichiro ; Kishimoto, Shun ; Devasahayam, Nallathamby ; Chandramouli, Gadisetti V. R. ; Ogawa, Yukihiro ; Matsumoto, Shingo ; Krishna, Murali C. ; Subramanian, Sankaran
著者名 Matsumoto, Ken-ichiro
著者名 Kishimoto, Shun
著者名 Devasahayam, Nallathamby
著者名 Chandramouli, Gadisetti V. R.
著者名 Ogawa, Yukihiro
e-Rad_Researcher 90741041 著者名 Matsumoto, Shingo
著者名 Krishna, Murali C.
著者名 Subramanian, Sankaran
言語	英語
キーワード	EPR imaging
	EPR oximetry
	in vivo oximetry
	partial oxygen pressure
	single-point imaging
	spin-lattice relaxation time
	triphenylmethyl radical
	tissue oxygen
発行日	2018-11
出版者	Wiley
収録物名	Magnetic Resonance in Medicine
巻(号)	80(5)
ページ	2275-2287
抄録	Purpose: Spin-lattice relaxation time (T1)-weighted time-domain EPR oximetry is reported for in vivo applications using a paramagnetic probe, a trityl-based Oxo71. Methods: The R1 dependence of the trityl probe Oxo71 on pO2 was assessed using single point imaging (SPI) mode of spatial encoding combined with rapid repetition, similar to T1-weighted MRI, where R1 was determined from 22 repetition times ranging from 2.1–40.0 μs at 300 MHz. The pO2 maps of a phantom with three tubes containing 2 mM Oxo71 solutions equilibrated at 0%, 2%, and 5% oxygen were determined by R1 and apparent spin-spin relaxation rate (R2) simultaneously. Results: The pO2 maps derived from R1 and R2 agreed with the known pO2 levels in the tubes of Oxo71. However, the histograms of pO2 revealed that R1 offers better pO2 resolution than R2* in low pO2 regions. The standard deviations of pixels at 2% pO2 (15.2 mmHg) were about 5 times lower in R1-based estimation than R2-based estimation (mean ± SD: 13.9 ± 1.77 mmHg and 18.3 ± 8.70 mmHg, respectively). The in vivo pO2 map obtained from R1-based assessment displayed a homogeneous profile in low pO2 regions in tumor xenografts, consistent with previous reports on R2-based oximetric imaging. The scan time to obtain the R1 map can be significantly reduced using three repetition times ranging from 4.0‒12.0 μs. Conclusion: Using the SPI modality, R1-based oximetry imaging with useful spatial and oxygen resolutions for small animals was demonstrated.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Matsumoto K‐i, Kishimoto S, Devasahayam N, et al. EPR‐based oximetric imaging: a combination of single point‐based spatial encoding and T1 weighting. Magn Reson Med. 2018;80(5):2275-2287. https://doi.org/10.1002/mrm.27182, which has been published in final form at https://doi.org/10.1002/mrm.27182. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PISSN	0740-3194
EISSN	1522-2594
NCID	AA10631284
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/mrm.27182