Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka : A Cross Sectional Study

Sarathkumara, Yomani D.; Gamage, Chandika D.; Lokupathirage, Sithumini; Muthusinghe, Devinda S.; Nanayakkara, Nishantha; Gunarathne, Lishanthe; Shimizu, Kenta; Tsuda, Yoshimi; Arikawa, Jiro; Yoshimatsu, Kumiko

Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka : A Cross Sectional Study

Sarathkumara, Yomani D.; Gamage, Chandika D.; Lokupathirage, Sithumini et al.

Viruses-Basel, 2019, 11(8), 700

Permalink : https://hdl.handle.net/2115/76131

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アクセス権	open access
URI	https://hdl.handle.net/2115/76131
タイトル	Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka : A Cross Sectional Study
著者	Sarathkumara, Yomani D. ; Gamage, Chandika D. ; Lokupathirage, Sithumini ; Muthusinghe, Devinda S. ; Nanayakkara, Nishantha ; Gunarathne, Lishanthe ; Shimizu, Kenta ; Tsuda, Yoshimi ; Arikawa, Jiro ; Yoshimatsu, Kumiko
著者名 Sarathkumara, Yomani D.
著者名 Gamage, Chandika D.
著者名 Lokupathirage, Sithumini
著者名 Muthusinghe, Devinda S.
著者名 Nanayakkara, Nishantha
著者名 Gunarathne, Lishanthe
e-Rad_Researcher 20466840 著者名 Shimizu, Kenta
著者名 Tsuda, Yoshimi
e-Rad_Researcher 10142704 著者名 Arikawa, Jiro
e-Rad_Researcher 90220722 著者名 Yoshimatsu, Kumiko
言語	英語
キーワード	Thailand orthohantavirus
	tropical nephropathy
	rodent
発行日	2019-08
出版者	MDPI
収録物名	Viruses-Basel
巻(号)	11(8)
ページ	700
抄録	Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants' demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/v11080700