Microbiome Alteration in Type 2 Diabetes Mellitus Model of Zebrafish

Okazaki, Fumiyoshi; Zang, Liqing; Nakayama, Hiroko et al.

Scientific Reports, 2019, 9(1), 867

Permalink : https://hdl.handle.net/2115/76133

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https://doi.org/10.1038/s41598-018-37242-x     18

論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/76133
タイトル
Microbiome Alteration in Type 2 Diabetes Mellitus Model of Zebrafish
著者
Okazaki, Fumiyoshi ; Zang, Liqing ; Nakayama, Hiroko ; Chen, Zhen ; Gao, Zi-Jun ; Chiba, Hitoshi ; Hui, Shu-Ping ; Aoki, Takahiko ; Nishimura, Norihiro ; Shimada, Yasuhito
著者名
Okazaki, Fumiyoshi
著者名
Zang, Liqing
著者名
Nakayama, Hiroko
著者名
Chen, Zhen
著者名
Gao, Zi-Jun
e-Rad_Researcher
70197622
著者名
Chiba, Hitoshi
e-Rad_Researcher
90337030
著者名
Hui, Shu-Ping
著者名
Aoki, Takahiko
著者名
Nishimura, Norihiro
著者名
Shimada, Yasuhito
言語
英語
発行日
2019-01-29
出版者
Springer Nature
収録物名
Scientific Reports
巻(号)
9(1)
ページ
867
抄録
Understanding the gut microbiota in metabolic disorders, including type 2 diabetes mellitus (T2DM), is now gaining importance due to its potential role in disease risk and progression. We previously established a zebrafish model of T2DM, which shows glucose intolerance with insulin resistance and responds to anti-diabetic drugs. In this study, we analysed the gut microbiota of T2DM zebrafish by deep sequencing the 16S rRNA V3-V4 hypervariable regions, and imputed a functional profile using predictive metagenomic tools. While control and T2DM zebrafish were fed with the same kind of feed, the gut microbiota in T2DM group was less diverse than that of the control. Predictive metagenomics profiling using PICRUSt revealed functional alternation of the KEGG pathways in T2DM zebrafish. Several amino acid metabolism pathways (arginine, proline, and phenylalanine) were downregulated in the T2DM group, similar to what has been previously reported in humans. In summary, we profiled the gut microbiome in T2DM zebrafish, which revealed functional similarities in gut bacterial environments between these zebrafish and T2DM affected humans. T2DM zebrafish can become an alternative model organism to study host-bacterial interactions in human obesity and related diseases.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
2045-2322
EISSN
2045-2322
関連情報
PMID
30696861
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1038/s41598-018-37242-x