Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months : The Hokkaido Study on Environment and Children's Health

Yamazaki, Keiko; Araki, Atsuko; Nakajima, Sonomi; Miyashita, Chihiro; Ikeno, Tamiko; Itoh, Sachiko; Minatoya, Machiko; Kobayashi, Sumitaka; Mizutani, Futoshi; Chisaki, Yoichi; Kishi, Reiko

Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months : The Hokkaido Study on Environment and Children's Health

Yamazaki, Keiko; Araki, Atsuko; Nakajima, Sonomi et al.

NeuroToxicology, 2018, 69, 201-208

Permalink : https://hdl.handle.net/2115/76214

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アクセス権	open access
URI	https://hdl.handle.net/2115/76214
タイトル	Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months : The Hokkaido Study on Environment and Children's Health
著者	Yamazaki, Keiko ; Araki, Atsuko ; Nakajima, Sonomi ; Miyashita, Chihiro ; Ikeno, Tamiko ; Itoh, Sachiko ; Minatoya, Machiko ; Kobayashi, Sumitaka ; Mizutani, Futoshi ; Chisaki, Yoichi ; Kishi, Reiko
e-Rad_Researcher 60732120 著者名 Yamazaki, Keiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
著者名 Nakajima, Sonomi
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 80569715 著者名 Ikeno, Tamiko
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
著者名 Mizutani, Futoshi
著者名 Chisaki, Yoichi
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Neurodevelopment
	Bayley Scales of Infant Development (BSID-II)
	Organochlorine pesticide
	Prenatal exposure
	Birth cohort
発行日	2018-12
出版者	Elsevier
収録物名	NeuroToxicology
巻(号)	69
ページ	201-208
抄録	Organochlorine pesticides (OCPs) are environmental contaminants that persist in the environment and bioaccumulate through the food chain in humans and animals. Although previous studies have shown an association between prenatal OCP exposure and subsequent neurodevelopment, the levels of OCPs included in these studies were inconsistent. A hospital-based prospective birth cohort study was conducted to examine the associations between prenatal exposure to relatively low levels of OCPs and neurodevelopment in infants at 6 (n = 164) and 18 (n = 115) months of age. Blood samples were analyzed using gas chromatography/mass spectrometry techniques to quantify 29 OCPs. The Bayley Scales of Infant Development 2nd edition (BSID-II) was used to assess the Mental and Psychomotor Developmental Index. After controlling for confounders, we found an inverse association between prenatal exposure to cis-heptachlor epoxide and the Mental Developmental Index at 18 months of age. Furthermore, infants born to mothers with prenatal concentrations of cis-heptachlor epoxide in the highest quartile had Mental Developmental Index scores -9.8 (95% confidence interval: -16.4, -3.1) lower than that recorded for infants born to mothers with concentrations of cis-heptachlor epoxide in the first quartile (p for trend < 0.01). These results support the hypothesis that prenatal exposure to OCPs, especially cis-heptachlor epoxide, may have an adverse effect on the neurodevelopment of infants at specific ages, even at low levels.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0161-813X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.neuro.2017.11.011