Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients

Fujima, N.; Hirata, K.; Shiga, T.; Li, R.; Yasuda, K.; Onimaru, R.; Tsuchiya, K.; Kano, S.; Mizumachi, T.; Homma, A.; Kudo, K.; Shirato, H.

Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients

Fujima, N.; Hirata, K.; Shiga, T. et al.

Clinical radiology, 2018, 73(12), 1059.e1-1059.e8

Permalink : https://hdl.handle.net/2115/76215

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アクセス権	open access
URI	https://hdl.handle.net/2115/76215
タイトル	Integrating quantitative morphological and intratumoural textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell carcinoma patients
著者	Fujima, N. ; Hirata, K. ; Shiga, T. ; Li, R. ; Yasuda, K. ; Onimaru, R. ; Tsuchiya, K. ; Kano, S. ; Mizumachi, T. ; Homma, A. ; Kudo, K. ; Shirato, H.
e-Rad_Researcher 80431360 著者名 Fujima, N.
e-Rad_Researcher 30431365 著者名 Hirata, K.
e-Rad_Researcher 80374495 著者名 Shiga, T.
著者名 Li, R.
著者名 Yasuda, K.
e-Rad_Researcher 80374461 著者名 Onimaru, R.
著者名 Tsuchiya, K.
e-Rad_Researcher 00374421 著者名 Kano, S.
e-Rad_Researcher 00507577 著者名 Mizumachi, T.
e-Rad_Researcher 30312359 著者名 Homma, A.
著者名 Kudo, K.
e-Rad_Researcher 20187537 著者名 Shirato, H.
言語	英語
発行日	2018-12
出版者	Elsevier
収録物名	Clinical radiology
巻(号)	73(12)
ページ	1059.e1-1059.e8
抄録	Aim: To assess potential prognostic factors in pharynx squamous cell carcinoma (SCC) patients by quantitative morphological and intratumoural characteristics obtained by 2-[18F]-fluoro-2-deoxy-d-glucose positron-emission tomography/computed tomography (FDG-PET/CT). Materials and methods: The cases of 54 patients with pharynx SCC who underwent chemoradiation therapy were analysed retrospectively. Using their FDG-PET data, the quantitative morphological and intratumoural characteristics of 14 parameters were calculated. The progression-free survival (PFS) and overall survival (OS) information was obtained from patient medical records. Univariate and multivariate analyses were performed to assess the 14 quantitative parameters as well as the T-stage, N-stage, and tumour location data for their relation to PFS and OS. When an independent predictor was suggested in the multivariate analysis, the parameter was further assessed using the Kaplan-Meier method. Results: In the assessment of PFS, the univariate and multivariate analyses indicated the following as independent predictors: the texture parameter of homogeneity and the morphological parameter of sphericity. In the Kaplan-Meier analysis, the PFS rate was significantly improved in the patients who had both a higher value of homogeneity (p=0.01) and a higher value of sphericity (p=0.002). With the combined use of homogeneity and sphericity, the patients with different PFS rates could be divided more clearly. Conclusion: The quantitative parameters of homogeneity and sphericity obtained by FDG-PET can be useful for the prediction of the PFS of pharynx SCC patients, especially when used in combination.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0009-9260
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.crad.2018.08.011