Serodiagnosis of elephant tuberculosis: a useful tool for early identification of infected elephants at the captive-wild interface

Paudel, Sarad; Mikota, Susan K.; Thapa, Jeewan; Lyashchenko, Konstantin P.; Gairhe, Kamal P.; Dhakal, Ishwari Prasad; Subedi, Naresh; Maharjan, Bhagwan; Subedi, Suraj; Kaufman, Gretchen E.; Tsubota, Toshio

Serodiagnosis of elephant tuberculosis: a useful tool for early identification of infected elephants at the captive-wild interface

Paudel, Sarad; Mikota, Susan K.; Thapa, Jeewan et al.

European journal of wildlife research, 2018, 64(6), 70

Permalink : https://hdl.handle.net/2115/76245

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アクセス権	open access
URI	https://hdl.handle.net/2115/76245
タイトル	Serodiagnosis of elephant tuberculosis: a useful tool for early identification of infected elephants at the captive-wild interface
著者	Paudel, Sarad ; Mikota, Susan K. ; Thapa, Jeewan ; Lyashchenko, Konstantin P. ; Gairhe, Kamal P. ; Dhakal, Ishwari Prasad ; Subedi, Naresh ; Maharjan, Bhagwan ; Subedi, Suraj ; Kaufman, Gretchen E. ; Tsubota, Toshio
著者名 Paudel, Sarad
著者名 Mikota, Susan K.
著者名 Thapa, Jeewan
著者名 Lyashchenko, Konstantin P.
著者名 Gairhe, Kamal P.
著者名 Dhakal, Ishwari Prasad
著者名 Subedi, Naresh
著者名 Maharjan, Bhagwan
著者名 Subedi, Suraj
著者名 Kaufman, Gretchen E.
e-Rad_Researcher 10207441 著者名 Tsubota, Toshio
言語	英語
キーワード	Asian elephants
	Tuberculosis
	DPP VetTB assay
	ElephantTB STAT-PAK
	Serological assay
発行日	2018-12
出版者	Springer
収録物名	European journal of wildlife research
巻(号)	64(6)
ページ	70
抄録	Tuberculosis (TB) is an emerging disease in elephants primarily caused by Mycobacterium tuberculosis (M. tb) and in some occassion by M. bovis. We performed culture and three serological teststhe Elephant TB STAT-PAK,(R) DPP VetTB (R) Assay, and MAPIA (multi-antigen print immunoassay)prospectively on samples from eight elephants in Nepal that died of suspected or confirmed tuberculosis (TB) between 2007 and 2013. Among them, all elephants were reactive to DPP VetTB (R) Assay, five to Elephant TB STAT-PAK,(R) and two were reactive to MAPIA. Similarly, six elephants were positive on culture on samples collected antemortem or postmortem. We observed antibody responses months to years before culture confirmation of TB which shows that serological tests can be highly useful for the early diagnosis of TB in elephants. Validated point-of-care serological tests are easily performed in the field and hold promise for improved TB surveillance in other non-domestic species.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1612-4642
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10344-018-1229-3