Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children : The Hokkaido Study

Bamai, Yu Ait; Bastiaensen, Michiel; Araki, Atsuko; Goudarzi, Houman; Konno, Satoshi; Ito, Sachiko; Miyashita, Chihiro; Yao, Yiming; Covaci, Adrian; Kishi, Reiko

Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children : The Hokkaido Study

Bamai, Yu Ait; Bastiaensen, Michiel; Araki, Atsuko et al.

Environment international, 2019, 131, UNSP 105003

Permalink : https://hdl.handle.net/2115/76300

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アクセス権	open access
URI	https://hdl.handle.net/2115/76300
タイトル	Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children : The Hokkaido Study
著者	Bamai, Yu Ait ; Bastiaensen, Michiel ; Araki, Atsuko ; Goudarzi, Houman ; Konno, Satoshi ; Ito, Sachiko ; Miyashita, Chihiro ; Yao, Yiming ; Covaci, Adrian ; Kishi, Reiko
e-Rad_Researcher 90752907 著者名 Bamai, Yu Ait
著者名 Bastiaensen, Michiel
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 40713607 著者名 Goudarzi, Houman
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
e-Rad_Researcher 90580936 著者名 Ito, Sachiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
著者名 Yao, Yiming
著者名 Covaci, Adrian
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Organophosphate flame retardant (PFR)
	Urinary metabolites
	Oxidative stress biomarkers
	Multiple exposures
発行日	2019-10
出版者	Elsevier
収録物名	Environment international
巻(号)	131
ページ	UNSP 105003
抄録	Organophosphate flame retardants (PFRs) are used as additives in plastics and other applications such as curtains and carpets as a replacement for brominated flame retardants. As such, exposure to PFR mixtures is widespread, with children being more vulnerable than adults to associated health risks such as allergies and inflammation. Oxidative stress is thought to be able to modulate the development of childhood airway inflammation and atopic dermatitis. To evaluate these associations, the present study investigated the relationship between urinary PFR metabolites, their mixtures and urinary oxidative stress biomarkers in children as part of the Hokkaido Study on Environment and Children's Health. The levels of the oxidative stress biomarkers, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), hexanoyl-lysine (HEL), and 4-hydroxynonenal (HNE), and of 14 PFR metabolites were measured in morning spot urine samples of 7-year-old children (n = 400). Associations between PFR metabolites or PFR metabolite mixtures and oxidative stress biomarkers were examined by multiple regression analysis and weighted quantile sum regression analysis, respectively. We found that the non-chlorinated PFR metabolites, 2-ethylhexyl phenyl phosphate (EHPHP), bis(2-butoxyethyl) phosphate (BBOEP), and diphenyl phosphate (DPHP) were associated with increased levels of oxidative stress biomarkers. Furthermore, the PFR metabolite mixture was associated with increased levels of HEL and HNE, but not 8-OHdG. The combination of elevated top 2 PFR metabolites was not associated with higher urinary oxidative stress marker levels. This is the first study to report associations between urinary PFR metabolites and oxidative stress biomarkers among children.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	0160-4120
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.envint.2019.105003