Genetic and antigenic characterization of bovine viral diarrhea viruses isolated from cattle in Hokkaido, Japan

Abe, Yuri; Tamura, Tomokazu; Torii, Shiho et al.

Journal of Veterinary Medical Science, 2016, 78(1), 61-70

Permalink : https://hdl.handle.net/2115/76355

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https://doi.org/10.1292/jvms.15-0186     17

論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/76355
タイトル
Genetic and antigenic characterization of bovine viral diarrhea viruses isolated from cattle in Hokkaido, Japan
著者
Abe, Yuri ; Tamura, Tomokazu ; Torii, Shiho ; Wakamori, Shiho ; Nagai, Makoto ; Mitsuhashi, Kazuya ; Mine, Junki ; Fujimoto, Yuri ; Nagashima, Naofumi ; Yoshino, Fumi ; Sugita, Yukihiko ; Nomura, Takushi ; Okamatsu, Masatoshi ; Kida, Hiroshi ; Sakoda, Yoshihiro
著者名
Abe, Yuri
著者名
Tamura, Tomokazu
著者名
Torii, Shiho
著者名
Wakamori, Shiho
著者名
Nagai, Makoto
著者名
Mitsuhashi, Kazuya
著者名
Mine, Junki
著者名
Fujimoto, Yuri
著者名
Nagashima, Naofumi
著者名
Yoshino, Fumi
著者名
Sugita, Yukihiko
著者名
Nomura, Takushi
e-Rad_Researcher
00507163
著者名
Okamatsu, Masatoshi
e-Rad_Researcher
10109506
著者名
Kida, Hiroshi
e-Rad_Researcher
40333637
著者名
Sakoda, Yoshihiro
言語
英語
キーワード
antigenicity
bovine viral diarrhea virus
E2
genetic diversity
発行日
2016-01
出版者
The Japanese Society of Veterinary Science
日本獣医学会
収録物名
Journal of Veterinary Medical Science
巻(号)
78(1)
ページ
61-70
抄録
In our previous study, we genetically analyzed bovine viral diarrhea viruses (BVDVs) isolated from 2000 to 2006 in Japan and reported that subgenotype 1b viruses were predominant. In the present study, 766 BVDVs isolated from 2006 to 2014 in Hokkaido, Japan, were genetically analyzed to understand recent epidemics. Phylogenetic analysis based on nucleotide sequences of the 5′-untranslated region of viral genome revealed that 766 isolates were classified as genotype 1 (BVDV-1; 544 isolates) and genotype 2 (BVDV-2; 222). BVDV-1 isolates were further divided into BVDV-1a (93), 1b (371) and 1c (80) subgenotypes, and all BVDV-2 isolates were grouped into BVDV-2a subgenotype (222). Further comparative analysis was performed with BVDV-1a, 1b and 2a viruses isolated from 2001 to 2014. Phylogenetic analysis based on nucleotide sequences of the viral glycoprotein E2 gene, a major target of neutralizing antibodies, revealed that BVDV-1a, 1b and 2a isolates were further classified into several clusters. Cross-neutralization tests showed that BVDV-1b isolates were antigenically different from BVDV-1a isolates, and almost BVDV-1a, 1b and 2a isolates were antigenically similar among each subgenotype and each E2 cluster. Taken together, BVDV-1b viruses are still predominant, and BVDV-2a viruses have increased recently in Hokkaido, Japan. Field isolates of BVDV-1a, 1b and 2a show genetic diversity on the E2 gene with antigenic conservation among each subgenotype during the last 14 years.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN
0916-7250
EISSN
1347-7439
NCID
AA10796138
関連情報
PMID
26400674
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1292/jvms.15-0186