Prenatal exposure to dioxin-like compounds is associated with decreased cord blood IgE and increased risk of wheezing in children aged up to 7 years : The Hokkaido study

Miyashita, Chihiro; Ait Bamai, Yu; Araki, Atsuko; Itoh, Sachiko; Minatoya, Machiko; Kobayashi, Sumitaka; Kajiwara, Jumboku; Hori, Tsuguhide; Kishi, Reiko

Prenatal exposure to dioxin-like compounds is associated with decreased cord blood IgE and increased risk of wheezing in children aged up to 7 years : The Hokkaido study

Miyashita, Chihiro; Ait Bamai, Yu; Araki, Atsuko et al.

Science of The Total Environment, 2018, 610-611, 191-199

Permalink : https://hdl.handle.net/2115/76441

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アクセス権	open access
URI	https://hdl.handle.net/2115/76441
タイトル	Prenatal exposure to dioxin-like compounds is associated with decreased cord blood IgE and increased risk of wheezing in children aged up to 7 years : The Hokkaido study
著者	Miyashita, Chihiro ; Ait Bamai, Yu ; Araki, Atsuko ; Itoh, Sachiko ; Minatoya, Machiko ; Kobayashi, Sumitaka ; Kajiwara, Jumboku ; Hori, Tsuguhide ; Kishi, Reiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 90752907 著者名 Ait Bamai, Yu
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
著者名 Kajiwara, Jumboku
著者名 Hori, Tsuguhide
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Dioxin-like compounds
	Prenatal exposure
	IgE
	Allergy
	Infection
	Children of school age
発行日	2018-01-01
出版者	Elsevier
収録物名	Science of The Total Environment
巻(号)	610-611
ページ	191-199
抄録	Introduction: In utero exposure to dioxin-like compounds (DLCs) may cause imbalance of immune development in early infancy. However, there are few epidemiological studies into the effects of in utero exposure to DLCs on allergies and infections during childhood. This study evaluates associations between concentrations of maternal DLCs and cord blood immunoglobulin (Ig) E, as well as allergies and infections during childhood. Method: We recruited 514 pregnant women in a maternity hospital in Sapporo, Japan, and measured concentrations of DLCs in 426 maternal blood samples using high-resolution gas chromatography/high-resolution mass spectrometry. We examined the relationship between concentrations of maternal DLCs and cord blood IgE at birth (n = 239), as well as for allergies and infections in children at 3.5 (n = 327) and 7 (n = 264) years, using regression analysis adjusted for confounding variables. Results: We found a positive association between maternal DLC concentrations and frequency of wheezing in children aged up to 7 years [odds ratio (OR); 7.81 (95% confidence interval (CI), 1.42 to 42.9)]. At 3.5 years, boys showed inverse associations between maternal DLC concentrations and cord blood IgE [partial regression coefficient; -0.87 (95% CI), -1.68 to -0.06], and frequency of wheezing [OR; 0.03 (95% CI), 0.00 to 0.94] but girls did not. Discussion: As one reason for the significant association observed at 7 but absent at 3.5 years, we suggest that allergic symptoms are more obvious in older children due to matured immune function. Conclusion: The findings suggest that prenatal exposure to DLCs may modify offspring immune responses and result in increased risk of allergy among children of school age.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0048-9697
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.scitotenv.2017.07.248