Comparison of antibody responses against Mycobacterium tuberculosis antigen Rv0679c in tuberculosis patients from the endemic and non-endemic regions of the Beijing genotype: a case control study

Zhao, Jingge; Matsuba, Takashi; Zhang, Xiaoyan; Leano, Susan; Nakajima, Chie; Chagan-Yasutan, Haorile; Telan, Elizabeth Freda; Suzuki, Yasuhiko; Hattori, Toshio

Comparison of antibody responses against Mycobacterium tuberculosis antigen Rv0679c in tuberculosis patients from the endemic and non-endemic regions of the Beijing genotype: a case control study

Zhao, Jingge; Matsuba, Takashi; Zhang, Xiaoyan et al.

BMC Infectious Diseases, 2017, 17(1), 344

Permalink : https://hdl.handle.net/2115/76483

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アクセス権	open access
URI	https://hdl.handle.net/2115/76483
タイトル	Comparison of antibody responses against Mycobacterium tuberculosis antigen Rv0679c in tuberculosis patients from the endemic and non-endemic regions of the Beijing genotype: a case control study
著者	Zhao, Jingge ; Matsuba, Takashi ; Zhang, Xiaoyan ; Leano, Susan ; Nakajima, Chie ; Chagan-Yasutan, Haorile ; Telan, Elizabeth Freda ; Suzuki, Yasuhiko ; Hattori, Toshio
著者名 Zhao, Jingge
e-Rad_Researcher 20304206 著者名 Matsuba, Takashi
著者名 Zhang, Xiaoyan
著者名 Leano, Susan
e-Rad_Researcher 60435964 著者名 Nakajima, Chie
e-Rad_Researcher 50624821 著者名 Chagan-Yasutan, Haorile
著者名 Telan, Elizabeth Freda
e-Rad_Researcher 90206540 著者名 Suzuki, Yasuhiko
e-Rad_Researcher 30172935 著者名 Hattori, Toshio
言語	英語
キーワード	Mycobacterium tuberculosis
	Dimorphic antigen
	Rv0679c
	Beijing genotype
	Philippines
	Immunoglobulin G
	Immunoglobulin A
発行日	2017-05-15
出版者	BioMed Central
収録物名	BMC Infectious Diseases
巻(号)	17(1)
ページ	344
抄録	Background:Strains of the Beijing genotype ofMycobacterium tuberculosis(MTB) are reportedly associated with thevirulence of tuberculosis (TB) infection, unfavorable outcomes of anti-TB treatment, and the global TB pandemic.Rv0679c, a hypothetical membrane protein related to host cell invasion, has a Beijing genotype-specific mutation atresidue 142 (Asn142Lys). Antigenicity differences between Rv0679c-Asn142 (N-type) and Rv0679c-Lys142 (K-type)have been previously observed in mice antigen-antibody responses. However, the immune response to Rv0679c inhumans remains unknown. Therefore, we aimed to investigate the anti-Rv0679c immune response in TB patientsfrom the endemic and non-endemic regions of the Beijing MTB genotype.Methods:We analyzed the Rv0679c-specific antibody responses in 84 subjects from the endemic region of the Beijinggenotype MTB in China, including 45 pulmonary TB patients (C-PTB) and 39 healthy controls (C-HC), and 81 subjectsfrom the Philippines (the endemic region of the non-Beijing genotype), including 51 pulmonary TB patients (P-PTB)and 30 healthy controls (P-HC). Anti-tuberculous-glycolipid (TBGL) antigen was used as the control antibody.Results:TBGL IgG titers were higher in both C-PTB and P-PTB than those in their corresponding HC (C-PTB median 4.2,P-PTB median 11.2; C-PTB vs. P-PTB,p> 0.05), suggesting immune response comparability in PTB from two differentcountries. C-PTB showed a higher response compared to C-HC for anti-K-type IgG (53.3%) than anti-N-type IgG (6.67%);this response was not observed in P-PTB (both N-type and K-type 9.80%).Conclusion:Dimorphic antigen Rv0679c was found to be associated with distinct immune response patterns,indicating the role of Beijing/non-Beijing genotype of MTB in stimulating specific responses in TB patients from theendemic region of Beijing MTB. Meanwhile, reactions to Rv0679c in patients and HC from non-endemic regions of theBeijing MTB may be caused by the response to the common epitope of Rv0679c N/K-type.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
EISSN	1471-2334
関連情報	PMID 28506215
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s12879-017-2442-5