Blonanserin suppresses impulsive action in rats

Nishitani, Naoya; Sasamori, Hitomi; Ohmura, Yu; Yoshida, Takayuki; Yoshioka, Mitsuhiro

Blonanserin suppresses impulsive action in rats

Nishitani, Naoya; Sasamori, Hitomi; Ohmura, Yu et al.

Journal of pharmacological sciences, 2019, 141(3), 127-130

Permalink : https://hdl.handle.net/2115/76506

このアイテムのアクセス数:595件（2026-10-09 23:50 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/76506
タイトル	Blonanserin suppresses impulsive action in rats
著者	Nishitani, Naoya ; Sasamori, Hitomi ; Ohmura, Yu ; Yoshida, Takayuki ; Yoshioka, Mitsuhiro
著者名 Nishitani, Naoya
著者名 Sasamori, Hitomi
e-Rad_Researcher 80597659 著者名 Ohmura, Yu
e-Rad_Researcher 60374229 著者名 Yoshida, Takayuki
e-Rad_Researcher 40182729 著者名 Yoshioka, Mitsuhiro
言語	英語
キーワード	Impulsive behavior
	1-PP
	Antipsychotics
発行日	2019-11
出版者	Japanese Pharmacological Society
収録物名	Journal of pharmacological sciences
巻(号)	141(3)
ページ	127-130
抄録	High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the administration of blonanserin, an atypical antipsychotic, reduced impulsive actions in a U-shaped manner. 1-(2-Pyriidinyl)-piperazine, an active metabolite of buspirone or tandospirone, also slightly reduced impulsive actions, though it impaired motor functions. These results affirm the validity of our strategy, but require its refinement for developing anti-impulsivity drugs. (C) 2019 The Authors. Production and hosting by Elsevier B.V.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1347-8613
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.jphs.2019.09.013