A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection

Fujioka, Yoichiro; Satoh, Aya O.; Horiuchi, Kosui; Fujioka, Mari; Tsutsumi, Kaori; Sasaki, Junko; Nepal, Prabha; Kashiwagi, Sayaka; Paudel, Sarad; Nishide, Shinya; Nanbo, Asuka; Sasaki, Takehiko; Ohba, Yusuke

A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection

Fujioka, Yoichiro; Satoh, Aya O.; Horiuchi, Kosui et al.

Cell structure and function, 2019, 44(1), 61-74

Permalink : https://hdl.handle.net/2115/76512

このアイテムのアクセス数:587件（2026-08-08 16:42 集計）

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https://doi.org/10.1247/csf.19001			10

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アクセス権	open access
URI	https://hdl.handle.net/2115/76512
タイトル	A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection
著者	Fujioka, Yoichiro ; Satoh, Aya O. ; Horiuchi, Kosui ; Fujioka, Mari ; Tsutsumi, Kaori ; Sasaki, Junko ; Nepal, Prabha ; Kashiwagi, Sayaka ; Paudel, Sarad ; Nishide, Shinya ; Nanbo, Asuka ; Sasaki, Takehiko ; Ohba, Yusuke
e-Rad_Researcher 70597492 著者名 Fujioka, Yoichiro
著者名 Satoh, Aya O.
著者名 Horiuchi, Kosui
著者名 Fujioka, Mari
e-Rad_Researcher 80344505 著者名 Tsutsumi, Kaori
e-Rad_Researcher 30333371 著者名 Sasaki, Junko
著者名 Nepal, Prabha
著者名 Kashiwagi, Sayaka
e-Rad_Researcher 30793939 著者名 Paudel, Sarad
e-Rad_Researcher 40451398 著者名 Nishide, Shinya
e-Rad_Researcher 60359487 著者名 Nanbo, Asuka
e-Rad_Researcher 50333365 著者名 Sasaki, Takehiko
e-Rad_Researcher 30333503 著者名 Ohba, Yusuke
言語	英語
キーワード	signal transduction
	endocytosis
	endosome
	imaging
	influenza virus
発行日	2019
出版者	Japan Society for Cell Biology
出版者	日本細胞生物学会
収録物名	Cell structure and function
巻(号)	44(1)
ページ	61-74
抄録	Endocytosis mediates the internalization and ingestion of a variety of endogenous or exogenous substances, including virus particles, under the control of intracellular signaling pathways. We have previously reported that the complex formed between the small GTPase Ras and phosphoinositide 3-kinase (PI3K) translocates from the plasma membrane to endosomes, signaling from which thereby regulates clathrin-independent endocytosis, endosome maturation, influenza virus internalization, and infection. However, the molecular mechanism by which the Ras-PI3K complex is recruited to endosomes remains unclear. Here, we have identified the amino acid sequence responsible for endosomal localization of the Ras-PI3K complex. PI3K lacking this sequence failed to translocate to endosomes, and expression of the peptide comprising this PI3K-derived sequence inhibited clathrin-independent endocytosis, influenza virus internalization, and infection. Moreover, treatment of cells with this peptide in an arginine-rich, cell-penetrating form successfully suppressed influenza virus infection in vitro and ex vivo, making this peptide a potential therapeutic agent against influenza virus infection.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	0386-7196
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1247/csf.19001