Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer.

Ujiie, Hideki; Kato, Tatsuya; Lee, Daiyoon; Hu, Hsin-Pei; Fujino, Kosuke; Kaji, Mitsuhito; Kaga, Kichizo; Matsui, Yoshiro; Yasufuku, Kazuhiro

Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer.

Ujiie, Hideki; Kato, Tatsuya; Lee, Daiyoon et al.

International journal of oncology, 2017, 50(6), 2154-2170

Permalink : https://hdl.handle.net/2115/76522

このアイテムのアクセス数:667件（2026-08-19 22:00 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer	pdf	1.29 MB	530

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/76522
タイトル	Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer.
著者	Ujiie, Hideki ; Kato, Tatsuya ; Lee, Daiyoon ; Hu, Hsin-Pei ; Fujino, Kosuke ; Kaji, Mitsuhito ; Kaga, Kichizo ; Matsui, Yoshiro ; Yasufuku, Kazuhiro
著者名 Ujiie, Hideki
著者名 Kato, Tatsuya
著者名 Lee, Daiyoon
著者名 Hu, Hsin-Pei
著者名 Fujino, Kosuke
e-Rad_Researcher 40322812 著者名 Kaji, Mitsuhito
e-Rad_Researcher 80224335 著者名 Kaga, Kichizo
e-Rad_Researcher 90219379 著者名 Matsui, Yoshiro
e-Rad_Researcher 60372356 著者名 Yasufuku, Kazuhiro
言語	英語
キーワード	biomarker
	EBUS-TBNA
	lung cancer
	MAGEA2
	p53
	therapeutic target
発行日	2017-06
収録物名	International journal of oncology
巻(号)	50(6)
ページ	2154-2170
抄録	Melanoma-associated antigens (MAGE) are expressed in different type of cancers including lung cancer and have been shown to be functionally related to p53 tumor suppressor gene. Little is known about the relationship between MAGE genes and p53 aberrant expression in lung cancer. The aims of this study were to observe the expression of MAGEA2, examine the role of MAGEA2 in lung cancer survival, investigate its correlation between MAGEA2 and p53, and explore its clinicopathologic significance as a prognostic marker. Quantitative reverse transcription-polymerase chain reaction was performed to detect the expression of MAGEA2 using 36 primary tumors and 31 metastatic lymph nodes from patients with lung cancer. The role of MAGEA2 in cancer cell growth and in the regulation of p53 downstream genes were examined using small interfering RNA. The expression of MAGEA2 and p53 were analyzed immunohistochemically using tissue microarray from 353 resected lung specimens. High-level expression of MAGEA2 (High-MAGEA2) was confirmed in lung tumors with high frequency. Inhibiting MAGEA2 expression effectively suppressed cancer cell growth and decreased the expression of p53 downstream target genes in vitro. In adenocarcinoma, High-MAGEA2 was strongly associated with aberrant p53 expression (P<0.001) and was associated with worse clinical outcomes (5-year OS, 87.1% in low vs. 74.1% in high, P=0.014). Aberrant p53 expression was also significant worse prognostic factor (P=0.029). Among the adenocarcinoma patients with wild-type p53, High-MAGEA2 had poorer prognosis than low-level MAGEA2 groups (5-year OS, 90.1% vs. 72.1%, P=0.037), whereas had no difference in p53 aberrant tumors. On multivariate analysis, MAGEA2 was independently associated with survival (hazard ratio; 2.12, P=0.030). In conclusion, suppression of MAGEA2 in lung cancer cells significantly reduced the growth/survival of cancer cells. High-MAGEA2 was identified as an independent prognostic factor in lung adenocarcinoma. Specific inhibition of MAGEA2 may be a promising therapeutic strategy for patients with lung cancer.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1791-2423
EISSN	1791-2423
関連情報	PMID 28498455
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3892/ijo.2017.3984