SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma.

Kato, Tatsuya; Lee, Daiyoon; Wu, Licun; Patel, Priya; Young, Ahn Jin; Wada, Hironobu; Hu, Hsin-Pei; Ujiie, Hideki; Kaji, Mitsuhito; Kano, Satoshi; Matsuge, Shinichi; Domen, Hiromitsu; Kanno, Hiromi; Hatanaka, Yutaka; Hatanaka, Kanako C; Kaga, Kichizo; Matsui, Yoshiro; Matsuno, Yoshihiro; De Perrot, Marc; Yasufuku, Kazuhiro

SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma.

Kato, Tatsuya; Lee, Daiyoon; Wu, Licun et al.

International journal of oncology, 2016, 49(6), 2411-2420

Permalink : https://hdl.handle.net/2115/76523

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アクセス権	open access
URI	https://hdl.handle.net/2115/76523
タイトル	SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma.
著者	Kato, Tatsuya ; Lee, Daiyoon ; Wu, Licun ; Patel, Priya ; Young, Ahn Jin ; Wada, Hironobu ; Hu, Hsin-Pei ; Ujiie, Hideki ; Kaji, Mitsuhito ; Kano, Satoshi ; Matsuge, Shinichi ; Domen, Hiromitsu ; Kanno, Hiromi ; Hatanaka, Yutaka ; Hatanaka, Kanako C ; Kaga, Kichizo ; Matsui, Yoshiro ; Matsuno, Yoshihiro ; De Perrot, Marc ; Yasufuku, Kazuhiro
著者名 Kato, Tatsuya
著者名 Lee, Daiyoon
著者名 Wu, Licun
著者名 Patel, Priya
著者名 Young, Ahn Jin
e-Rad_Researcher 90514604 著者名 Wada, Hironobu
著者名 Hu, Hsin-Pei
著者名 Ujiie, Hideki
e-Rad_Researcher 40322812 著者名 Kaji, Mitsuhito
e-Rad_Researcher 00374421 著者名 Kano, Satoshi
著者名 Matsuge, Shinichi
著者名 Domen, Hiromitsu
著者名 Kanno, Hiromi
e-Rad_Researcher 30589924 著者名 Hatanaka, Yutaka
著者名 Hatanaka, Kanako C
e-Rad_Researcher 80224335 著者名 Kaga, Kichizo
e-Rad_Researcher 90219379 著者名 Matsui, Yoshiro
e-Rad_Researcher 00199829 著者名 Matsuno, Yoshihiro
著者名 De Perrot, Marc
e-Rad_Researcher 60372356 著者名 Yasufuku, Kazuhiro
言語	英語
キーワード	SORORIN
	cell division cycle associated 5 (CDCA5)
	polo like kinase 1
	therapeutic target genes
	immunohistochemistry
	malignant pleural mesothelioma
発行日	2016-12
出版者	D.A. Spandidos
収録物名	International journal of oncology
巻(号)	49(6)
ページ	2411-2420
抄録	Malignant pleural mesothelioma (MPM) is an aggressive type of cancer of the thoracic cavity commonly associated with asbestos exposure and a high mortality rate. There is a need for new molecular targets for the development of more effective therapies for MPM. Using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and an RNA interference-based screening, we examined the SORORIN gene as potential therapeutic targets for MPM in addition to the PLK1 gene, which is known for kinase of SORORIN. Following in vitro investigation of the effects of target silencing on MPM cells, cell cycle analyses were performed. SORORIN expression was analyzed immunohistochemically using a total of 53 MPM samples on tissue microarray. SORORIN was found to be overexpressed in the majority of clinical MPM samples and human MPM cell lines as determined by qRT-PCR. Gene suppression of each SORORIN and PLK1 led to growth inhibition in MPM cell lines. Knockdown of SORORIN showed an increased number of G2M-phase population and a larger nuclear size, suggesting mitotic arrest. High expression of SORORIN (SORORIN-H) was found in 50.9% of all the MPM cases, and there is a tendency towards poorer prognosis for the SORORIN-H group but the difference is not significant. Suppression of SORORIN with PLK1 inhibitor BI 6727 showed a combinational growth suppressive effect on MPM cell growth. Given high-dose PLK1 inhibitor induced drug-related adverse effects in several clinical trials, our results suggest inhibition SORORIN-PLK1 axis may hold promise for the treatment of MPMs.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1791-2423
関連情報	PMID 27840913
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3892/ijo.2016.3765