Myeloid differentiation factor 88 signaling in donor T cells accelerates graft-versus-host disease

Matsuoka, Satomi; Hashimoto, Daigo; Kadowaki, Masanori; Ohigashi, Hiroyuki; Hayase, Eiko; Yokoyama, Emi; Hasegawa, Yuta; Tateno, Takahiro; Chen, Xuanzhong; Aoyama, Kazutoshi; Oka, Hideyo; Onozawa, Masahiro; Takeda, Kiyoshi; Akashi, Koichi; Teshima, Takanori

Myeloid differentiation factor 88 signaling in donor T cells accelerates graft-versus-host disease

Matsuoka, Satomi; Hashimoto, Daigo; Kadowaki, Masanori et al.

Haematologica, 2020, 105(1), 226-234

Permalink : https://hdl.handle.net/2115/76613

このアイテムのアクセス数:729件（2026-10-05 21:50 集計）

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https://doi.org/10.3324/haematol.2018.203380			22

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アクセス権	open access
URI	https://hdl.handle.net/2115/76613
タイトル	Myeloid differentiation factor 88 signaling in donor T cells accelerates graft-versus-host disease
著者	Matsuoka, Satomi ; Hashimoto, Daigo ; Kadowaki, Masanori ; Ohigashi, Hiroyuki ; Hayase, Eiko ; Yokoyama, Emi ; Hasegawa, Yuta ; Tateno, Takahiro ; Chen, Xuanzhong ; Aoyama, Kazutoshi ; Oka, Hideyo ; Onozawa, Masahiro ; Takeda, Kiyoshi ; Akashi, Koichi ; Teshima, Takanori
著者名 Matsuoka, Satomi
e-Rad_Researcher 20419576 著者名 Hashimoto, Daigo
著者名 Kadowaki, Masanori
著者名 Ohigashi, Hiroyuki
著者名 Hayase, Eiko
著者名 Yokoyama, Emi
著者名 Hasegawa, Yuta
著者名 Tateno, Takahiro
著者名 Chen, Xuanzhong
著者名 Aoyama, Kazutoshi
著者名 Oka, Hideyo
e-Rad_Researcher 70455632 著者名 Onozawa, Masahiro
e-Rad_Researcher 20309446 著者名 Takeda, Kiyoshi
e-Rad_Researcher 80380385 著者名 Akashi, Koichi
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
発行日	2020-01-01
出版者	Ferrata Storti Foundation
収録物名	Haematologica
巻(号)	105(1)
ページ	226-234
抄録	Myeloid differentiation factor 88 (MyD88) signaling has a crucial role in activation of both innate and adoptive immunity. MyD88 transduces signals via Toll-like receptor and interleukin-1 receptor superfamily to the NF kappa B pathway and inflammasome by forming a molecular complex with interleukin-1 receptor-associated kinase 4. The MyD88/interleukin-1 receptor-associated kinase 4 pathway plays an important role, not only in innate immunity, but also T-cell immunity; however, its role in donor T cells on the pathophysiology of graft-versus-host disease (GvHD) remains to be elucidated. We addressed this issue by using MyD88-deficient T cells in a mouse model of allogeneic hematopoietic stem cell transplantation (allo-SCT). While MyD88-deficient and wild-type T cells proliferated equivalently after transplantation, MyD88-deficient T cells demonstrated impaired survival and differentiation toward Th1, Tc1, and Th17, and induced less severe GvHD compared to wild-type T cells. Administration of interleukin-1 receptor-associated kinase 4 inhibitor PF-06650833 significantly ameliorated GvHD after allo-SCT. These results thus demonstrate that donor T-cell receptor-associated kinase 4 pathway is a novel therapeutic target against GvHD after allo-SCT.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	0390-6078
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3324/haematol.2018.203380