Noradrenaline reuptake inhibition increases control of impulsive action by activating D1-like receptors in the infralimbic cortex

Sasamori, Hitomi; Ohmura, Yu; Yoshida, Takayuki; Yoshioka, Mitsuhiro

Noradrenaline reuptake inhibition increases control of impulsive action by activating D1-like receptors in the infralimbic cortex

Sasamori, Hitomi; Ohmura, Yu; Yoshida, Takayuki et al.

European journal of pharmacology, 2019, 844, 17-25

Permalink : https://hdl.handle.net/2115/76693

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/76693
タイトル	Noradrenaline reuptake inhibition increases control of impulsive action by activating D1-like receptors in the infralimbic cortex
著者	Sasamori, Hitomi ; Ohmura, Yu ; Yoshida, Takayuki ; Yoshioka, Mitsuhiro
著者名 Sasamori, Hitomi
e-Rad_Researcher 80597659 著者名 Ohmura, Yu
e-Rad_Researcher 60374229 著者名 Yoshida, Takayuki
e-Rad_Researcher 40182729 著者名 Yoshioka, Mitsuhiro
言語	英語
キーワード	Impulsivity
	Impulsive behavior
	Behavioral inhibition
	SNRI
	Microdialysis
	Dopamine
発行日	2019-02-05
出版者	Elsevier
収録物名	European journal of pharmacology
巻(号)	844
ページ	17-25
抄録	Higher impulsivity is a risk factor for criminal involvement, substance abuse, and suicide. However, only a few drugs are clinically available for the treatment of deficient impulse control. We recently proposed a strategy for identifying potential drugs to treat such disorders by investigating clinically available drugs that increase extracellular dopamine levels in the medial prefrontal cortex and stimulate dopamine D1-like receptors without increasing extracellular dopamine levels in the ventral striatum. To determine whether this strategy is promising, we examined the effects of duloxetine, a serotonin-noradrenaline reuptake inhibitor that might meet these criteria, on impulsive action in adult male Wistar/ST rats using a 3-choice serial reaction time task. The effects of duloxetine on extracellular dopamine levels in the medial prefrontal cortex and nucleus accumbens, a part of the ventral striatum were evaluated using in vivo microdialysis, as the noradrenaline transporter transports dopamine in some brain regions. Our results showed that the administration of duloxetine reduced impulsive actions and increased extracellular dopamine levels in the mPFC but not in the nucleus accumbens. Microinjection of a selective D1-like receptor antagonist into the infralimbic cortex blocked the suppression of impulsive action by duloxetine. In addition, we demonstrated that the microinjection also blocked the suppression of impulsive action by atomoxetine, a noradrenaline reuptake inhibitor and an established anti-impulsive drug. These results support our proposed strategy for identifying and developing anti-impulsivity drugs.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0014-2999
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ejphar.2018.11.041