Paclitaxel-associated Acute Pain Syndrome Similarly Occurs in the Patients with or without Previously Administered Non-steroidal Anti-inflammatory Drugs Prior to Paclitaxel Administration

Saito, Yoshitaka; Yamada, Takehiro; Kobayashi, Masaki; Sakakibara-Konishi, Jun; Shinagawa, Naofumi; Kinoshita, Ichiro; Dosaka-Akita, Hirotoshi; Iseki, Ken

Paclitaxel-associated Acute Pain Syndrome Similarly Occurs in the Patients with or without Previously Administered Non-steroidal Anti-inflammatory Drugs Prior to Paclitaxel Administration

Saito, Yoshitaka; Yamada, Takehiro; Kobayashi, Masaki et al.

薬学雑誌　Yakugaku zasshi（Journal of the pharmaceutical society of Japan）, 2019, 139(12), 1601-1608

Permalink : https://hdl.handle.net/2115/76725

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https://doi.org/10.1248/yakushi.19-00148			16

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アクセス権	open access
URI	https://hdl.handle.net/2115/76725
タイトル	Paclitaxel-associated Acute Pain Syndrome Similarly Occurs in the Patients with or without Previously Administered Non-steroidal Anti-inflammatory Drugs Prior to Paclitaxel Administration
著者	Saito, Yoshitaka ; Yamada, Takehiro ; Kobayashi, Masaki ; Sakakibara-Konishi, Jun ; Shinagawa, Naofumi ; Kinoshita, Ichiro ; Dosaka-Akita, Hirotoshi ; Iseki, Ken
著者名 Saito, Yoshitaka
著者名 Yamada, Takehiro
e-Rad_Researcher 70431319 著者名 Kobayashi, Masaki
著者名 Sakakibara-Konishi, Jun
著者名 Shinagawa, Naofumi
著者名 Kinoshita, Ichiro
著者名 Dosaka-Akita, Hirotoshi
e-Rad_Researcher 40203062 著者名 Iseki, Ken
言語	英語
キーワード	paclitaxel
	paclitaxel-associated acute pain syndrome
	pain
	non-steroidal anti-inflammatory drugs
	arthralgia
	myalgia
発行日	2019-12
出版者	The Pharmaceutical Society of Japan （日本薬学会）
収録物名	薬学雑誌　Yakugaku zasshi（Journal of the pharmaceutical society of Japan）
巻(号)	139(12)
ページ	1601-1608
抄録	Paclitaxel (PTX)-associated acute pain syndrome (P-APS) is characterized by disabling but transient arthralgia and myalgia in up to 80% of patients administered with PTX. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely administered to patients with cancer who have pain or fever, and are mainly used to manage P-APS. In this study, we investigated how P-APS appear in the patients who were administered NSAIDs prior to PTX injection. The incidence or severity and duration of P-APS in patients previously administered NSAIDs were compared to those of patients who were not administered NSAIDs. The relationship between previously administered NSAIDs and rescue administration for the relief of P-APS was also evaluated. It was revealed that the incidence and duration of P-APS were 72% and 4.67 +/- 2.30 d, respectively, in the control group and 84% and 6.19 +/- 3.30 d, respectively, in the NSAIDs group. There was no significant difference in the incidence and duration and the severity of P-APS between the two groups. Patients who were previously administered NSAIDs tended to obtain less pain relief from NSAIDs administered as rescue medications, and needed other medication. Univariate and multivariate analysis revealed no correlation between previously administered NSAIDs or patient characteristics and the incidence of P-APS. In this study, it was found that clinical condition that needs NSAIDs and previously administered NSAIDs prior to PTX injection do not affect the incidence, severity, and duration of P-APS. These results will help in educating patients about their medications and will contribute to the management of P-APS.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Copyright 2019 The Pharmaceutical Society of Japan
PISSN	0031-6903
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1248/yakushi.19-00148