Association of prenatal exposure to PCDD/Fs and PCBs with maternal and infant thyroid hormones : The Hokkaido Study on Environment and Children's Health

Baba, Toshiaki; Ito, Sachiko; Yuasa, Motoyuki; Yoshioka, Eiji; Miyashita, Chihiro; Araki, Atsuko; Sasaki, Seiko; Kobayashi, Sumitaka; Kajiwara, Jumboku; Hori, Tsuguhide; Kato, Shizue; Kishi, Reiko

Association of prenatal exposure to PCDD/Fs and PCBs with maternal and infant thyroid hormones : The Hokkaido Study on Environment and Children's Health

Baba, Toshiaki; Ito, Sachiko; Yuasa, Motoyuki et al.

Science of The Total Environment, 2018, 615, 1239-1246

Permalink : https://hdl.handle.net/2115/76744

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アクセス権	open access
URI	https://hdl.handle.net/2115/76744
タイトル	Association of prenatal exposure to PCDD/Fs and PCBs with maternal and infant thyroid hormones : The Hokkaido Study on Environment and Children's Health
著者	Baba, Toshiaki ; Ito, Sachiko ; Yuasa, Motoyuki ; Yoshioka, Eiji ; Miyashita, Chihiro ; Araki, Atsuko ; Sasaki, Seiko ; Kobayashi, Sumitaka ; Kajiwara, Jumboku ; Hori, Tsuguhide ; Kato, Shizue ; Kishi, Reiko
著者名 Baba, Toshiaki
e-Rad_Researcher 90580936 著者名 Ito, Sachiko
e-Rad_Researcher 30463748 著者名 Yuasa, Motoyuki
e-Rad_Researcher 70435957 著者名 Yoshioka, Eiji
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
著者名 Kajiwara, Jumboku
著者名 Hori, Tsuguhide
著者名 Kato, Shizue
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Dioxins
	PCBs
	Thyroid hormones
	Prenatal exposure
	Birth cohort
発行日	2018-02-15
出版者	Elsevier
収録物名	Science of The Total Environment
巻(号)	615
ページ	1239-1246
抄録	Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs) are persistent organic pollutants that are universally detected. Some congeners of PCDDs, PCDFs or PCBs have dioxin-like toxicity, whereas non-dioxin-like PCBs are considered to have different toxicity. Reports of the relationships between prenatal exposure to PCDDs, PCDFs or PCBs and thyroid homeostasis in pregnant women and infants have been inconsistent. The aim of this study was to investigate the effect of maternal serum PCDD/F or PCB levels on maternal and neonatal thyroid hormone (TH) levels in a prospective cohort. Of the 514 subjects in the prospective cohort, 386 mothers and 410 infants were included for analysis. Fifteen dioxins and seventy PCBs in maternal blood collected between 23 and 41 weeks of gestation were measured using high-resolution gas chromatography and high-resolution mass spectrometry. Blood samples to measure thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from mothers at an early gestational stage (median ten weeks), and from infants between four and seven days of age, respectively. Multiple linear regression analysis was conducted. Median concentration of total PCBs, PCB 153 were 104,700, and 20,500 pg/g lipid, respectively. Median total dioxin-TEQ was 13.8 pg/g lipid. Total dioxin-TEQ, coplanar PCBs were positively associated with neonatal FT4 (beta = 0.224, 0.206, respectively). The association was stronger in boys (beta = 0.299, 0.282, respectively). Several PCDD/F and PCB isomers were also positively associated with neonatal FT4. Total PCBs or non-dioxin-like PCBs were not associated with any maternal or neonatal THs. No DLC grouping or congeners were associated with neonatal TSH. Non-ortho PCBs were positively associated with maternal FT4. Three PCB congeners had significant positive association(s) with maternal THs. In conclusion, the results of our study suggest that perinatal exposure to background-level DLCs increases neonatal FT4, especially in boys.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0048-9697
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.scitotenv.2017.09.038