Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

Takada, Shingo; Kinugawa, Shintaro; Hirabayashi, Kagami; Suga, Tadashi; Yokota, Takashi; Takahashi, Masashige; Fukushima, Arata; Homma, Tsuneaki; Ono, Taisuke; Sobirin, Mochamad A.; Masaki, Yoshihiro; Mizushima, Wataru; Kadoguchi, Tomoyasu; Okita, Koichi; Tsutsui, Hiroyuki

Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

Takada, Shingo; Kinugawa, Shintaro; Hirabayashi, Kagami et al.

Journal of Applied Physiology, 2013, 114(7), 844-857

Permalink : https://hdl.handle.net/2115/76769

このアイテムのアクセス数:555件（2026-08-24 21:40 集計）

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https://doi.org/10.1152/japplphysiol.00053.2012			26

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アクセス権	open access
URI	https://hdl.handle.net/2115/76769
タイトル	Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice
著者	Takada, Shingo ; Kinugawa, Shintaro ; Hirabayashi, Kagami ; Suga, Tadashi ; Yokota, Takashi ; Takahashi, Masashige ; Fukushima, Arata ; Homma, Tsuneaki ; Ono, Taisuke ; Sobirin, Mochamad A. ; Masaki, Yoshihiro ; Mizushima, Wataru ; Kadoguchi, Tomoyasu ; Okita, Koichi ; Tsutsui, Hiroyuki
e-Rad_Researcher 60722329 著者名 Takada, Shingo
e-Rad_Researcher 60399871 著者名 Kinugawa, Shintaro
著者名 Hirabayashi, Kagami
著者名 Suga, Tadashi
e-Rad_Researcher 90374321 著者名 Yokota, Takashi
著者名 Takahashi, Masashige
e-Rad_Researcher 40706553 著者名 Fukushima, Arata
著者名 Homma, Tsuneaki
著者名 Ono, Taisuke
著者名 Sobirin, Mochamad A.
著者名 Masaki, Yoshihiro
著者名 Mizushima, Wataru
著者名 Kadoguchi, Tomoyasu
e-Rad_Researcher 80382539 著者名 Okita, Koichi
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
言語	英語
キーワード	oxidative stress
	angiotensin
	diabetes
	mitochondria
	muscle
発行日	2013
出版者	American Physiological Society
収録物名	Journal of Applied Physiology
巻(号)	114(7)
ページ	844-857
抄録	NAD(P)H oxidase-induced oxidative stress is at least in part involved with lowered exercise capacity and impaired mitochondrial function in high-fat diet (HFD)-induced diabetic mice. NAD(P)H oxidase can be activated by activation of the renin-angiotensin system. We investigated whether ANG II receptor blocker can improve exercise capacity in diabetic mice. C57BL/6J mice were fed a normal diet (ND) or HFD, and each group of mice was divided into two groups: treatment with or without olmesartan (OLM; 3 mg·kg−1·day−1 in the drinking water). The following groups of mice were studied: ND, ND+OLM, HFD, and HFD+OLM (n = 10 for each group). After 8 wk, HFD significantly increased body weight, plasma glucose, and insulin compared with ND, and OLM did not affect these parameters in either group. Exercise capacity, as determined by treadmill tests, was significantly reduced in HFD, and this reduction was ameliorated in HFD+OLM. ADP-dependent mitochondrial respiration was significantly decreased, and NAD(P)H oxidase activity and superoxide production by lucigenin chemiluminescence were significantly increased in skeletal muscle from HFD, which were attenuated by OLM. There were no such effects by OLM in ND. We concluded that OLM ameliorated the decrease in exercise capacity in diabetic mice via improvement in mitochondrial function and attenuation of oxidative stress in skeletal muscle. These data may have a clinical impact on exercise capacity in the medical treatment of diabetes mellitus.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	8750-7587
EISSN	1522-1601
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1152/japplphysiol.00053.2012