(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice

Fukushima, Arata; Kinugawa, Shintaro; Takada, Shingo; Matsushima, Shouji; Sobirin, Mochamad Ali; Ono, Taisuke; Takahashi, Masashige; Suga, Tadashi; Homma, Tsuneaki; Masaki, Yoshihiro; Furihata, Takaaki; Kadoguchi, Tomoyasu; Yokota, Takashi; Okita, Koichi; Tsutsui, Hiroyuki

(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice

Fukushima, Arata; Kinugawa, Shintaro; Takada, Shingo et al.

American Journal of Physiology-Endocrinology and Metabolism, 2014, 307(6), E503-E514

Permalink : https://hdl.handle.net/2115/76770

このアイテムのアクセス数:605件（2026-10-08 16:09 集計）

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ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1152/ajpendo.00449.2013			34

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アクセス権	open access
URI	https://hdl.handle.net/2115/76770
タイトル	(Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice
著者	Fukushima, Arata ; Kinugawa, Shintaro ; Takada, Shingo ; Matsushima, Shouji ; Sobirin, Mochamad Ali ; Ono, Taisuke ; Takahashi, Masashige ; Suga, Tadashi ; Homma, Tsuneaki ; Masaki, Yoshihiro ; Furihata, Takaaki ; Kadoguchi, Tomoyasu ; Yokota, Takashi ; Okita, Koichi ; Tsutsui, Hiroyuki
e-Rad_Researcher 40706553 著者名 Fukushima, Arata
e-Rad_Researcher 60399871 著者名 Kinugawa, Shintaro
e-Rad_Researcher 60722329 著者名 Takada, Shingo
e-Rad_Researcher 80552869 著者名 Matsushima, Shouji
著者名 Sobirin, Mochamad Ali
著者名 Ono, Taisuke
著者名 Takahashi, Masashige
著者名 Suga, Tadashi
著者名 Homma, Tsuneaki
著者名 Masaki, Yoshihiro
著者名 Furihata, Takaaki
著者名 Kadoguchi, Tomoyasu
e-Rad_Researcher 90374321 著者名 Yokota, Takashi
e-Rad_Researcher 80382539 著者名 Okita, Koichi
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
言語	英語
キーワード	(pro)renin receptor
	renin-angiotensin system
	oxidative stress
	insulin resistance
	heart failure
発行日	2014
出版者	American Physiological Society
収録物名	American Journal of Physiology-Endocrinology and Metabolism
巻(号)	307(6)
ページ	E503-E514
抄録	We previously reported that insulin resistance was induced by the impairment of insulin signaling in the skeletal muscle from heart failure (HF) via NAD(P)H oxidase-dependent oxidative stress. (Pro)renin receptor [(P)RR] is involved in the activation of local renin-angiotensin system and subsequent oxidative stress. We thus examined whether (P)RR inhibitor, handle region peptide (HRP), could ameliorate insulin resistance in HF after myocardial infarction (MI) by improving oxidative stress and insulin signaling in the skeletal muscle. C57BL6J mice were divided into four groups: sham operated (Sham, n = 10), Sham treated with HRP (Sham+HRP, 0.1 mg·kg−1·day−1, n = 10), MI operated (MI, n = 10), and MI treated with HRP (MI+HRP, 0.1 mg/kg/day, n = 10). After 4 wk, MI mice showed left ventricular dysfunction, which was not affected by HRP. (P)RR was upregulated in the skeletal muscle after MI (149% of sham, P < 0.05). The decrease in plasma glucose after insulin load was smaller in MI than in Sham (21 ± 2 vs. 44 ± 3%, P < 0.05), and was greater in MI+HRP (38 ± 2%, P < 0.05) than in MI. Insulin-stimulated serine phosphorylation of Akt and glucose transporter 4 translocation were decreased in the skeletal muscle from MI by 48 and 49% of Sham, both of which were ameliorated in MI+HRP. Superoxide production and NAD(P)H oxidase activities were increased in MI, which was inhibited in MI+HRP. HRP ameliorated insulin resistance associated with HF by improving insulin signaling via the inhibition of NAD(P)H oxidase-induced superoxide production in the skeletal muscle. The (P)RR pathway is involved in the development of insulin resistance, at least in part, via the impairment of insulin signaling in the skeletal muscle from HF.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0193-1849
EISSN	1522-1555
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1152/ajpendo.00449.2013