Outcome of Living-Donor Liver Transplantation Using Grafts from Donors Treated for Fatty Liver

Fujii, Yuki; Kawamura, Norio; Zaitsu, Masaaki; Watanabe, Masaaki; Goto, Ryoichi; Kamiyama, Toshiya; Taketomi, Akinobu; Shimamura, Tsuyoshi

Outcome of Living-Donor Liver Transplantation Using Grafts from Donors Treated for Fatty Liver

Fujii, Yuki; Kawamura, Norio; Zaitsu, Masaaki et al.

Annals of transplantation, 2020, 25, UNSP e920677

Permalink : https://hdl.handle.net/2115/76802

このアイテムのアクセス数:637件（2026-10-07 23:00 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/76802
タイトル	Outcome of Living-Donor Liver Transplantation Using Grafts from Donors Treated for Fatty Liver
著者	Fujii, Yuki ; Kawamura, Norio ; Zaitsu, Masaaki ; Watanabe, Masaaki ; Goto, Ryoichi ; Kamiyama, Toshiya ; Taketomi, Akinobu ; Shimamura, Tsuyoshi
著者名 Fujii, Yuki
e-Rad_Researcher 20746953 著者名 Kawamura, Norio
e-Rad_Researcher 20768981 著者名 Zaitsu, Masaaki
e-Rad_Researcher 40789848 著者名 Watanabe, Masaaki
e-Rad_Researcher 10645287 著者名 Goto, Ryoichi
e-Rad_Researcher 80322816 著者名 Kamiyama, Toshiya
e-Rad_Researcher 70363364 著者名 Taketomi, Akinobu
e-Rad_Researcher 00333617 著者名 Shimamura, Tsuyoshi
言語	英語
キーワード	Diet Therapy
	Fatty Liver
	Liver Transplantation
	Living Donors
発行日	2020-01-10
出版者	International Scientific Information, Inc.
収録物名	Annals of transplantation
巻(号)	25
ページ	UNSP e920677
抄録	Background: The aim of this study was to determine the efficacy of treating donors' fatty liver (FL) and to assess early graft function in recipients who received treated FL grafts in living-donor liver transplantation (LDLT). Material/Methods: Data were collected for adult-to-adult LDLTs. Donors diagnosed with FL (FL group) received diet-exercise and pharmacological treatment. The perioperative findings and early transplanted graft function were compared with those of donors without FL (non-FL group) during the same period. Results: Of 30 donors, 8 were determined to have FL The median duration of treatment for FL was 58 days. The liver-to- spleen attenuation ratios on CT scan in the FL group were significantly improved after treatment: 0.95 (0.62-1.06) to 1.2 (1.12-1.46) (P=0.003). Liver biopsy prior to donor surgery showed <= 10% fatty infiltration. Postoperative laboratory findings of the donors in the FL group were comparable to those in the non-FL group: maximum alanine transaminase (189.6 +/- 94.7 IU/L vs. 196.8 +/- 57.4) and maximum total bilirubin (2.2 +/- 1.1 mg/dl vs. 1.7 +/- 0.5 mg/dL). No major complications were observed after donor hepatectomy in either group. There were no significant differences between the 2 groups in early graft function, as evaluated by laboratory data, ascites volume, and bile production 2 weeks postoperatively. Graft and patient survival were 100% in both groups at 3 months. Conclusions: Preoperative intentional treatment for FL was effective. Early graft function and donor postoperative course were comparable in the 2 groups. These results suggest that well-treated steatotic grafts can be used without jeopardizing donor safety.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1425-9524
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.12659/AOT.920677