Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5′- and 3′-UTRs

Yasuda, Motoaki; Hatanaka, Tomoyuki; Shirato, Hiroki; Nishioka, Takeshi

Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5′- and 3′-UTRs

Yasuda, Motoaki; Hatanaka, Tomoyuki; Shirato, Hiroki et al.

Biochemical and Biophysical Research Communications, 2014, 447(4), 638-643

Permalink : https://hdl.handle.net/2115/76837

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アクセス権	open access
URI	https://hdl.handle.net/2115/76837
タイトル	Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5′- and 3′-UTRs
著者	Yasuda, Motoaki ; Hatanaka, Tomoyuki ; Shirato, Hiroki ; Nishioka, Takeshi
e-Rad_Researcher 90239765 著者名 Yasuda, Motoaki
著者名 Hatanaka, Tomoyuki
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
e-Rad_Researcher 80271659 著者名 Nishioka, Takeshi
言語	英語
キーワード	Hypoxia
	HIF-1α
	UTR
	Translation
	Transcription
発行日	2014-05-16
出版者	Elsevier
収録物名	Biochemical and Biophysical Research Communications
巻(号)	447(4)
ページ	638-643
抄録	In the present study, we demonstrated the reciprocal regulation of hypoxia-inducible factor 1 alpha (HIF1A) gene expression via untranslated region-(UTR) dependent mechanisms. A 151 nucleotide sequence found in the HIF1A 5′-UTR is sufficient for significant translational up-regulation. On the other hand, the 3′-UTR of HIF1A has been implicated in mRNA degradation. In the non-metastatic breast cancer cell line MCF7, the 3′-UTR-dependent down-regulatory machinery predominates over the 5′-UTR-dependent up-regulation of HIF1A. However, 5′-UTR-dependent up-regulation is dominant among metastatic cell lines (MDA-MB453, U87MG). It is therefore likely that the predominance of 5′-UTR-dependent translational enhancement of HIF1A is critical for the malignant phenotype of cancer cells. PTBP-1, but not HuR, is a candidate RNA binding protein for the translational control of HIF1A.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© <2014>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0006-291X
NCID	AA00564395
関連情報	PMID 24769203
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2014.04.058