Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates

Itoh, Yasushi; Shichinohe, Shintaro; Nakayama, Misako; Igarashi, Manabu; Ishii, Akihiro; Ishigaki, Hirohito; Ishida, Hideaki; Kitagawa, Naoko; Sasamura, Takako; Shiohara, Masanori; Doi, Michiko; Tsuchiya, Hideaki; Nakamura, Shinichiro; Okamatsu, Masatoshi; Sakoda, Yoshihiro; Kida, Hiroshi; Ogasawara, Kazumasa

Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates

Itoh, Yasushi; Shichinohe, Shintaro; Nakayama, Misako et al.

Antimicrobial agents and chemotherapy, 2015, 59(8), 4962-4973

Permalink : https://hdl.handle.net/2115/76878

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https://doi.org/10.1128/AAC.00793-15			38

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/76878
タイトル	Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates
著者	Itoh, Yasushi ; Shichinohe, Shintaro ; Nakayama, Misako ; Igarashi, Manabu ; Ishii, Akihiro ; Ishigaki, Hirohito ; Ishida, Hideaki ; Kitagawa, Naoko ; Sasamura, Takako ; Shiohara, Masanori ; Doi, Michiko ; Tsuchiya, Hideaki ; Nakamura, Shinichiro ; Okamatsu, Masatoshi ; Sakoda, Yoshihiro ; Kida, Hiroshi ; Ogasawara, Kazumasa
e-Rad_Researcher 90324566 著者名 Itoh, Yasushi
e-Rad_Researcher 80737148 著者名 Shichinohe, Shintaro
e-Rad_Researcher 00510306 著者名 Nakayama, Misako
e-Rad_Researcher 10374240 著者名 Igarashi, Manabu
e-Rad_Researcher 90421982 著者名 Ishii, Akihiro
e-Rad_Researcher 90432301 著者名 Ishigaki, Hirohito
著者名 Ishida, Hideaki
著者名 Kitagawa, Naoko
著者名 Sasamura, Takako
著者名 Shiohara, Masanori
著者名 Doi, Michiko
e-Rad_Researcher 10378440 著者名 Tsuchiya, Hideaki
e-Rad_Researcher 50307980 著者名 Nakamura, Shinichiro
e-Rad_Researcher 00507163 著者名 Okamatsu, Masatoshi
e-Rad_Researcher 40333637 著者名 Sakoda, Yoshihiro
e-Rad_Researcher 10109506 著者名 Kida, Hiroshi
e-Rad_Researcher 20169163 著者名 Ogasawara, Kazumasa
言語	英語
発行日	2015-08
出版者	American Society for Microbiology
収録物名	Antimicrobial agents and chemotherapy
巻(号)	59(8)
ページ	4962-4973
抄録	The number of patients infected with H7N9 influenza virus has been increasing since 2013. We examined the efficacy of neuraminidase (NA) inhibitors and the efficacy of a vaccine against an H7N9 influenza virus, A/Anhui/1/2013 (H7N9), isolated from a patient in a cynomolgus macaque model. NA inhibitors (oseltamivir and peramivir) barely reduced the total virus amount because of the emergence of resistant variants with R289K or I219T in NA [residues 289 and 219 in N9 of A/Anhui/1/2013 (H7N9) correspond to 292 and 222 in N2, respectively] in three of the six treated macaques, whereas subcutaneous immunization of an inactivated vaccine derived from A/duck/Mongolia/119/2008 (H7N9) prevented propagation of A/Anhui/1/2013 (H7N9) in all vaccinated macaques. The percentage of macaques in which variant H7N9 viruses with low sensitivity to the NA inhibitors were detected was much higher than that of macaques in which variant H5N1 highly pathogenic influenza virus was detected after treatment with one of the NA inhibitors in our previous study. The virus with R289K in NA was reported in samples from human patients, whereas that with I219T in NA was identified for the first time in this study using macaques, though no variant H7N9 virus was reported in previous studies using mice. Therefore, the macaque model enables prediction of the frequency of emerging H7N9 virus resistant to NA inhibitors in vivo. Since H7N9 strains resistant to NA inhibitors might easily emerge compared to other influenza viruses, monitoring of the emergence of variants is required during treatment of H7N9 influenza virus infection with NA inhibitors.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0066-4804
EISSN	1098-6596
NCID	AA00542574
関連情報	PMID 26055368
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1128/AAC.00793-15