Prenatal tobacco exposure and ADHD symptoms at pre-school age : the Hokkaido Study on Environment and Children's Health

Minatoya, Machiko; Araki, Atsuko; Itoh, Sachiko; Yamazaki, Keiko; Kobayashi, Sumitaka; Miyashita, Chihiro; Sasaki, Seiko; Kishi, Reiko

Prenatal tobacco exposure and ADHD symptoms at pre-school age : the Hokkaido Study on Environment and Children's Health

Minatoya, Machiko; Araki, Atsuko; Itoh, Sachiko et al.

Environmental Health and Preventive Medicine, 2019, 24(1), 74

Permalink : https://hdl.handle.net/2115/76919

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https://doi.org/10.1186/s12199-019-0834-4			11

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アクセス権	open access
URI	https://hdl.handle.net/2115/76919
タイトル	Prenatal tobacco exposure and ADHD symptoms at pre-school age : the Hokkaido Study on Environment and Children's Health
著者	Minatoya, Machiko ; Araki, Atsuko ; Itoh, Sachiko ; Yamazaki, Keiko ; Kobayashi, Sumitaka ; Miyashita, Chihiro ; Sasaki, Seiko ; Kishi, Reiko
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 60732120 著者名 Yamazaki, Keiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	ADHD
	Prenatal tobacco exposure
	Passive smoking
	Birth cohort
	SDQ
発行日	2019-12
出版者	Springer
収録物名	Environmental Health and Preventive Medicine
巻(号)	24(1)
ページ	74
抄録	Background There have been inconsistent findings reported on maternal passive smoking during pregnancy and child risk of ADHD. In this study, ADHD symptoms at pre-school age children in association with prenatal passive and active tobacco smoke exposure determined by maternal plasma cotinine levels in the third trimester were investigated. Methods This was a follow-up study of the birth cohort: the Hokkaido Study on Environment and Children's Health. Children whose parents answered Strengths and Difficulties Questionnaire (SDQ) to identify child ADHD symptoms (hyperactivity/inattention and conduct problems) and total difficulties at age 5 years with available maternal plasma cotinine level at the third trimester were included (n = 3216). Cotinine levels were categorized into 4 groups; <= 0.21 ng/ml (non-smoker), 0.22-0.51 ng/ml (low-passive smoker), 0.52-11.48 ng/ml (high-passive smoker), and >= 11.49 ng/ml (active smoker). Results Maternal cotinine levels of active smokers were significantly associated with an increased risk of total difficulties (OR = 1.67) and maternal low- and high-passive smoking also increased the risk (OR = 1.11, 1.25, respectively) without statistical significance. Similarly, maternal cotinine levels of active smokers were associated with an increased risk of hyperactivity/inattention (OR = 1.49). Maternal low- and high-passive smoking and active smoking increased the risk of hyperactivity/inattention (OR = 1.45, 1.43, and OR = 1.59, respectively) only in boys. Conclusion Our findings suggested that maternal active smoking during pregnancy may contribute to the increased risk of child total difficulties and hyperactivity/inattention at pre-school age. Pregnant women should be encouraged to quit smoking and avoid exposure to tobacco smoke.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1342-078X
関連情報	PMID 31812162
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s12199-019-0834-4