Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

Takadate, Yoshihiro; Kondoh, Tatsunari; Igarashi, Manabu; Maruyama, Junki; Manzoor, Rashid; Ogawa, Hirohito; Kajihara, Masahiro; Furuyama, Wakako; Sato, Masahiro; Miyamoto, Hiroko; Yoshida, Reiko; Hill, Terence E.; Freiberg, Alexander N.; Feldmann, Heinz; Marzi, Andrea; Takada, Ayato

Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

Takadate, Yoshihiro; Kondoh, Tatsunari; Igarashi, Manabu et al.

Cell Reports, 2020, 30(2), 308-319.e5

Permalink : https://hdl.handle.net/2115/76927

このアイテムのアクセス数:795件（2026-10-12 10:14 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1016/j.celrep.2019.12.042			23

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/76927
タイトル	Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism
著者	Takadate, Yoshihiro ; Kondoh, Tatsunari ; Igarashi, Manabu ; Maruyama, Junki ; Manzoor, Rashid ; Ogawa, Hirohito ; Kajihara, Masahiro ; Furuyama, Wakako ; Sato, Masahiro ; Miyamoto, Hiroko ; Yoshida, Reiko ; Hill, Terence E. ; Freiberg, Alexander N. ; Feldmann, Heinz ; Marzi, Andrea ; Takada, Ayato
著者名 Takadate, Yoshihiro
著者名 Kondoh, Tatsunari
e-Rad_Researcher 10374240 著者名 Igarashi, Manabu
著者名 Maruyama, Junki
著者名 Manzoor, Rashid
e-Rad_Researcher 80455237 著者名 Ogawa, Hirohito
e-Rad_Researcher 70711894 著者名 Kajihara, Masahiro
著者名 Furuyama, Wakako
著者名 Sato, Masahiro
著者名 Miyamoto, Hiroko
著者名 Yoshida, Reiko
著者名 Hill, Terence E.
著者名 Freiberg, Alexander N.
著者名 Feldmann, Heinz
著者名 Marzi, Andrea
e-Rad_Researcher 10292062 著者名 Takada, Ayato
言語	英語
発行日	2020-01-14
出版者	Cell Press
収録物名	Cell Reports
巻(号)	30(2)
ページ	308-319.e5
抄録	Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species. Here, we show a molecular basis underlying the host-range restriction of filoviruses. We find that bat-derived cell lines FBKT1 and ZFBK13-76E show preferential susceptibility to EBOV and MARV, respectively, whereas the other bat cell lines tested are similarly infected with both viruses. In FBKT1 and ZFBK13-76E, unique amino acid (aa) sequences are found in the Niemann-Pick C1 (NPC1) protein, one of the cellular receptors interacting with the filovirus glycoprotein (GP). These aa residues, as well as a few aa differences between EBOV and MARV GPs, are crucial for the differential susceptibility to filoviruses. Taken together, our findings indicate that the heterogeneity of bat NPC1 orthologs is an important factor controlling filovirus species-specific host tropism.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
EISSN	2211-1247
関連情報	PMID 31940478
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.celrep.2019.12.042