Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases : The Hokkaido Study on Environment and Children's Health

Ait Bamai, Yu; Miyashita, Chihiro; Araki, Atsuko; Nakajima, Tamie; Sasaki, Seiko; Kishi, Reiko

Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases : The Hokkaido Study on Environment and Children's Health

Ait Bamai, Yu; Miyashita, Chihiro; Araki, Atsuko et al.

Science of the total environment, 2018, 618, 1408-1415

Permalink : https://hdl.handle.net/2115/76952

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アクセス権	open access
URI	https://hdl.handle.net/2115/76952
タイトル	Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases : The Hokkaido Study on Environment and Children's Health
その他のタイトル	Maternal DEHP and childhood allergies and infectious diseases
著者	Ait Bamai, Yu ; Miyashita, Chihiro ; Araki, Atsuko ; Nakajima, Tamie ; Sasaki, Seiko ; Kishi, Reiko
著者名 Ait Bamai, Yu
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
著者名 Nakajima, Tamie
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	di(2-Ethylhexyl) phthalate
	Allergies
	Infectious diseases
	Immunoglobulin E
	Prenatal exposure
	Children
発行日	2018-03-15
出版者	Elsevier
収録物名	Science of the total environment
巻(号)	618
ページ	1408-1415
抄録	Phthalates are widely used in consumer products, and experimental studies suggest that exposure to phthalates increase the risk of allergies. However, epidemiologic evidence on the associations between prenatal phthalate exposure and allergies/infectious diseases and cord blood immunoglobulin E (IgE) levels is limited. This study aimed to evaluate the associations between maternal mono(2-ethylhexyl) phthalate (MEHP) levels and cord blood IgE levels at birth (n = 127), as well as the risk of allergies/infectious diseases in participants up to 7 years of age; the participants were 1.5 (n = 248), 3.5 (n = 222), 7 (n = 184) years of age. Maternal blood MEHP level in the second trimester was measured using gas chromatography-mass spectrometry. Participant characteristics were obtained from the medical birth records and self-administered questionnaires during pregnancy and after delivery. Wheeze and eczema were defined according to the Japanese version of the International Study of Asthma and Allergies in Childhood and the American Thoracic Society-Division of Lung Diseases questionnaire, respectively. Infectious diseases were defined using questionnaires for each specified age. To evaluate the associations between maternal MEHP and allergies or infectious diseases, we used logistic regression analysis and generalized estimating equations analysis. Maternal MEHP levels were negatively associated with cord blood IgE levels and increased risks of allergies and infectious diseases up to 7 years of age. This is the first study to investigate the effects of prenatal MEHP exposure on IgE levels at birth and allergies/infectious diseases up to 7 years of age. Further epidemiological studies should focus on other phthalate metabolites and their health effects on larger populations.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0048-9697
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.scitotenv.2017.09.270