Sleep-Disordered Breathing Is an Independent Risk Factor of Aborted Sudden Cardiac Arrest in Patients With Coronary Artery Spasm

Sakakibara, Mamoru; Yamada, Shiro; Kamiya, Kiwamu; Yokota, Takashi; Oba, Koji; Tsutsui, Hiroyuki

Sleep-Disordered Breathing Is an Independent Risk Factor of Aborted Sudden Cardiac Arrest in Patients With Coronary Artery Spasm

Sakakibara, Mamoru; Yamada, Shiro; Kamiya, Kiwamu et al.

Circulation Journal, 2012, 76(9), 2204-2210

Permalink : https://hdl.handle.net/2115/76972

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アクセス権	open access
URI	https://hdl.handle.net/2115/76972
タイトル	Sleep-Disordered Breathing Is an Independent Risk Factor of Aborted Sudden Cardiac Arrest in Patients With Coronary Artery Spasm
著者	Sakakibara, Mamoru ; Yamada, Shiro ; Kamiya, Kiwamu ; Yokota, Takashi ; Oba, Koji ; Tsutsui, Hiroyuki
e-Rad_Researcher 90349366 著者名 Sakakibara, Mamoru
著者名 Yamada, Shiro
e-Rad_Researcher 60797108 著者名 Kamiya, Kiwamu
e-Rad_Researcher 90374321 著者名 Yokota, Takashi
著者名 Oba, Koji
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
言語	英語
キーワード	Autonomic nervous function
	Coronary artery spasm
	Fatal arrhythmia
	Sleep-disordered breathing
	Sudden cardiac arrest
発行日	2012
出版者	The Japanese Circulation Society
出版者	社団法人日本循環器学会
収録物名	Circulation Journal
巻(号)	76(9)
ページ	2204-2210
抄録	Background: Sleep-disordered breathing (SDB) is often associated with sudden cardiac arrest (SCA) during sleep. Coronary artery spasm (CS) also occurs during sleep and is rarely associated with SCA, but the role of SDB in the risk of SCA is unknown in CS patients. This study evaluated the breathing patterns during sleep in CS patients with a prior history of aborted SCA. Methods and Results: This study enrolled 24 patients (age 61.6±11.0 years, male/female 19/5) with CS proven by an acetylcholine provocation test. They were divided into 2 groups: prior history of aborted SCA due to fatal arrhythmia (SCA group; n=9) and no such history (no-SCA group; n=15). Patients underwent overnight polysomnography with ambulatory electrocardiography. The overall prevalence of SDB (apnea hypopnea index ≥15) was 45.8% in this cohort. SDB was more frequent in the SCA group than in the no-SCA group (88.9% vs. 20.0% P=0.001) and identified as a pivotal risk factor of aborted SCA (odds ratio: 38.9, 95% CI: 2.80–1,498.2, P=0.01). Very-low-frequency was significantly correlated with the apnea hypopnea index in patients with SCA (P=0.01, r=0.78) during sleep. Conclusions: SDB is a significant risk factor for SCA in CS patients and autonomic instability during sleep might be involved in this association. (Circ J 2012; 76: 2204–2210)
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	1346-9843
EISSN	1347-4820
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1253/circj.CJ-12-0210