open access

https://hdl.handle.net/2115/77135

Iridium(I)-Catalyzed C-H Borylation in Air by Using Mechanochemistry

英語

synthetic method

2019-03-27

Wiley-Blackwell

Chemistry-A European journal

25(18)

4654-4659

Mechanochemistry has been applied for the first time to an iridium(I)-catalyzed C-H borylation reaction. By using either none or just a catalytic amount of a liquid, the mechanochemical C-H borylation of a series of heteroaromatic compounds proceeded in air to afford the corresponding arylboronates in good-to-excellent yields. A one-pot mechanochemical C-H borylation/Suzuki-Miyaura cross-coupling sequence for the direct synthesis of 2-aryl indole derivatives is also described. The present study constitutes an important milestone towards the development of industrially attractive solvent-free C-H bond functionalization processes in air.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Yadong Pang, Tatsuo Ishiyama, Koji Kubota, and Hajime Ito. Iridium(I)‐Catalyzed C−H Borylation in Air by Using Mechanochemistry. Chemistry: A European Journal. March 27 2019, 25(18), p. 4654 - 4659, which has been published in final form at https://doi.org/10.1002/chem.201900685 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

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