open access

https://hdl.handle.net/2115/77188

Prognoses and Clinicopathological Characteristics for Hepatocellular Carcinoma Originating from the Caudate Lobe After Surgery

英語

portal invasion

2019-04

Springer

World journal of surgery

43(4)

1085-1093

BackgroundThe aim was to evaluate the prognoses and clinicopathological characteristics of solitary hepatocellular carcinoma (HCC) originating from the caudate lobe (HCC-CL).MethodsWe analyzed 584 patients with a solitary tumor <10cm from January 1990 to November 2014. Patients were classified into a caudate lobe group (CL; n=39) and a non-caudate lobe group (NCL; n=545). We investigated the prognoses and clinicopathological characteristics of solitary HCC-CL. We compared the surgical procedures performed in these cases.ResultsHCC-CL had a similar rate of portal venous invasion (PVI) as HCC-NCL (21% vs. 19%); however, the frequency of tumor thrombus at the first branch of the portal vein (PV) or extension to the trunk or the opposite side of the PV was significantly higher in HCC-CL (8% vs. 2%). HCC-CL had similar OS rates compared to HCC-NCL; however, HCC-CL showed significantly poorer RFS. Although there were no significant differences among the three surgical procedures, blood loss and complication rates tended to be higher in cases who underwent an isolated caudate lobectomy. Tumor size 5cm, PVI, and liver fibrosis or cirrhosis (LF or LC) were independent unfavorable factors for both OS and RFS. PIVKA-II 120mAU/ml was an independent unfavorable factor for RFS.ConclusionHCC-CL presented a poorer RFS rate. Patients with a tumor size 5cm, PIVKA-II 120mAU/ml, portal venous invasion, and LF or LC should be diligently followed up as these cases have a high risk of recurrence.

学術雑誌論文

Accepted Manuscript

The original publication is available at www.springerlink.com

0364-2313