Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana

Bortey-Sam, Nesta; Ikenaka, Yoshinori; Akoto, Osei; Nakayama, Shouta M. M.; Asante, Kwadwo A.; Baidoo, Elvis; Obirikorang, Christian; Mizukawa, Hazuki; Ishizuka, Mayumi

Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana

Bortey-Sam, Nesta; Ikenaka, Yoshinori; Akoto, Osei et al.

Environmental pollution, 2018, 235, 163-170

Permalink : https://hdl.handle.net/2115/77193

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アクセス権	open access
URI	https://hdl.handle.net/2115/77193
タイトル	Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana
著者	Bortey-Sam, Nesta ; Ikenaka, Yoshinori ; Akoto, Osei ; Nakayama, Shouta M. M. ; Asante, Kwadwo A. ; Baidoo, Elvis ; Obirikorang, Christian ; Mizukawa, Hazuki ; Ishizuka, Mayumi
著者名 Bortey-Sam, Nesta
著者名 Ikenaka, Yoshinori
著者名 Akoto, Osei
著者名 Nakayama, Shouta M. M.
著者名 Asante, Kwadwo A.
著者名 Baidoo, Elvis
著者名 Obirikorang, Christian
著者名 Mizukawa, Hazuki
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Metals
	Urine
	Kumasi
	Asthma
	DNA damage
発行日	2018-04
出版者	Elsevier
収録物名	Environmental pollution
巻(号)	235
ページ	163-170
抄録	Heavy metals and metalloids contamination in soils, water, food and livers of wild rats have been studied in Kumasi, Ghana and despite the estimated risks to residents, there is no epidemiological study to ascertain these projections. In addition, the World Health Organization and International Agency for Research on Cancer have reported an increase in respiratory diseases and cancers, in Ghana. The study's purpose was therefore to explore the potential associations between metal exposure and occurrences of respiratory diseases, lipid peroxidation and/or DNA damage to different age groups and sexes in Kumasi. Human urine was collected from the general population in urban and control sites in Kumasi and nine metals were measured in each sample. Results showed that although Zn was the most abundant total urinary As concentration was higher in 83% of samples compared to reference values. Urinary concentrations of metals, malondialdehyde (MDA) and 8-hydroxy-2-deoxy-guanosine (8-OHdG) were higher in urban sites compared to the control site. Based on the results obtained, there was no significant correlation between urinary metals and age. However, urinary Cd and MDA were highest in age groups 61-85 and 3-20 years, respectively. Significantly higher levels of urinary Co, As and Cd were detected in female participants. The study revealed that exposure to As was significantly associated with increased odds of asthma (odds ratio (OR) = 2.76; CI: 1.11-6.83) and tachycardia (OR = 3.93; CI: 1.01-15.4). Significant association was observed between urinary metals and MDA and 8-OHdG indicating possibility of lipid peroxidation and/or DNA damage in Kumasi residents. (C) 2017 Elsevier Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0269-7491
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.envpol.2017.12.005