Per cent low attenuation volume and fractal dimension of low attenuation clusters on CT predict different long-term outcomes in COPD

Shimizu, Kaoruko; Tanabe, Naoya; Tho, Nguyen Van; Suzuki, Masaru; Makita, Hironi; Sato, Susumu; Muro, Shigeo; Mishima, Michiaki; Hirai, Toyohiro; Ogawa, Emiko; Nakano, Yasutaka; Konno, Satoshi; Nishimura, Masaharu

Per cent low attenuation volume and fractal dimension of low attenuation clusters on CT predict different long-term outcomes in COPD

Shimizu, Kaoruko; Tanabe, Naoya; Tho, Nguyen Van et al.

Thorax, 2020, 75(2), 116-122

Permalink : https://hdl.handle.net/2115/77579

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/77579
タイトル	Per cent low attenuation volume and fractal dimension of low attenuation clusters on CT predict different long-term outcomes in COPD
著者	Shimizu, Kaoruko ; Tanabe, Naoya ; Tho, Nguyen Van ; Suzuki, Masaru ; Makita, Hironi ; Sato, Susumu ; Muro, Shigeo ; Mishima, Michiaki ; Hirai, Toyohiro ; Ogawa, Emiko ; Nakano, Yasutaka ; Konno, Satoshi ; Nishimura, Masaharu
e-Rad_Researcher 40399853 著者名 Shimizu, Kaoruko
e-Rad_Researcher 30805817 著者名 Tanabe, Naoya
著者名 Tho, Nguyen Van
e-Rad_Researcher 10374290 著者名 Suzuki, Masaru
e-Rad_Researcher 70533537 著者名 Makita, Hironi
e-Rad_Researcher 40378691 著者名 Sato, Susumu
e-Rad_Researcher 60344454 著者名 Muro, Shigeo
e-Rad_Researcher 60190625 著者名 Mishima, Michiaki
e-Rad_Researcher 20359805 著者名 Hirai, Toyohiro
e-Rad_Researcher 00378671 著者名 Ogawa, Emiko
e-Rad_Researcher 00362377 著者名 Nakano, Yasutaka
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
言語	英語
キーワード	computed tomography
	emphysema
	exacerbation
	fractal analysis
	prognosis
発行日	2020-02
出版者	BMJ Publishing Group
収録物名	Thorax
巻(号)	75(2)
ページ	116-122
抄録	Background Fractal dimension (D) characterises the size distribution of low attenuation clusters on CT and assesses the spatial heterogeneity of emphysema that per cent low attenuation volume (%LAV) cannot detect. This study tested the hypothesis that %LAV and D have different roles in predicting decline in FEV1, exacerbation and mortality in patients with COPD. Methods Chest inspiratory CT scans in the baseline and longitudinal follow-up records for FEV1, exacerbation and mortality prospectively collected over 10 years in the Hokkaido COPD Cohort Study were examined (n=96). The associations between CT measures and long-term outcomes were replicated in the Kyoto University cohort (n=130). Results In the Hokkaido COPD cohort, higher %LAV, but not D, was associated with a greater decline in FEV1 and 10-year mortality, whereas lower D, but not %LAV, was associated with shorter time to first exacerbation. Multivariable analysis for the Kyoto University cohort confirmed that lower D at baseline was independently associated with shorter time to first exacerbation and that higher LAV% was independently associated with increased mortality after adjusting for age, height, weight, FEV1 and smoking status. Conclusion These well-established cohorts clarify the different prognostic roles of %LAV and D, whereby lower D is associated with a higher risk of exacerbation and higher %LAV is associated with a rapid decline in lung function and long-term mortality. Combination of %LAV and fractal D may identify COPD subgroups at high risk of a poor clinical outcome more sensitively.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This article has been accepted for publication in [Journal, Year]following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/thoraxjnl-2019-213525. c Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
PISSN	0040-6376
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1136/thoraxjnl-2019-213525