Palladium-Catalyzed Decarboxylative Alkynylation of alpha-Acyloxyketones by C(sp(3))-O Bond Cleavage

Doi, Ryohei; Yabuta, Akimasa; Sato, Yoshihiro

Chemistry-A European journal, 2019, 25(23), 5884-5888

Permalink : https://hdl.handle.net/2115/77644

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アクセス権
open access
URI
https://hdl.handle.net/2115/77644
タイトル
Palladium-Catalyzed Decarboxylative Alkynylation of alpha-Acyloxyketones by C(sp(3))-O Bond Cleavage
著者
Doi, Ryohei ; Yabuta, Akimasa ; Sato, Yoshihiro
著者名
Doi, Ryohei
著者名
Yabuta, Akimasa
e-Rad_Researcher
90226019
著者名
Sato, Yoshihiro
言語
英語
キーワード
alkynylation
decarboxylation
enolates
ketones
palladium
発行日
2019-04-23
出版者
Wiley-Blackwell
収録物名
Chemistry-A European journal
巻(号)
25(23)
ページ
5884-5888
抄録
Palladium-catalyzed decarboxylative alkynylation of alpha-acyloxyketones triggered by C(sp(3))-O bond cleavage is disclosed. The decarboxylation strategy featuring a neutral reaction condition enabled an unprecedent catalytic alkynylation of a ketone enolate. The reaction was applied to a variety of substrates, giving desired products in good yields. We successfully obtained X-ray crystallography of a new palladium-enolate intermediate that was synthesized by a reaction of [Pd(cod)(CH2TMS)(2)] with XPhos and alpha-acyloxyketone at room temperature, indicating facile C(sp(3))-O bond disconnection.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This is the peer-reviewed version of the following article: https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201900582, which has been published in final form at 10.1002/chem.201900582. This article may be used for non-commercial purposes in accordance with Wiley-VCH Terms and Conditions for Self-Archiving.
PISSN
0947-6539
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1002/chem.201900582