Dose‐dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study

Kobayashi, Sumitaka; Sata, Fumihiro; Murata, Katsuyuki; Saijo, Yasuaki; Araki, Atsuko; Miyashita, Chihiro; Itoh, Sachiko; Minatoya, Machiko; Yamazaki, Keiko; Ait Bamai, Yu; Kishi, Reiko; Kawamoto, Toshihiro; Saito, Hirohisa; Yaegashi, Nobuo; Hashimoto, Koichi; Mori, Chisato; Itoh, Shuichi; Yamagata, Zentaro; Inadera, Hidekuni; Kamijima, Michihiro; Nakayama, Takeo; Iso, Hiroyasu; Shima, Masayuki; Hirooka, Yasuaki; Suganuma, Narufumi; Kusuhara, Koichi; Katoh, Takahiko

Dose‐dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study

Kobayashi, Sumitaka; Sata, Fumihiro; Murata, Katsuyuki et al.

Paediatric and Perinatal Epidemiology, 2019, 33(3), 185-194

Permalink : https://hdl.handle.net/2115/77805

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アクセス権	open access
URI	https://hdl.handle.net/2115/77805
タイトル	Dose‐dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study
著者	Kobayashi, Sumitaka ; Sata, Fumihiro ; Murata, Katsuyuki ; Saijo, Yasuaki ; Araki, Atsuko ; Miyashita, Chihiro ; Itoh, Sachiko ; Minatoya, Machiko ; Yamazaki, Keiko ; Ait Bamai, Yu ; Kishi, Reiko ; Kawamoto, Toshihiro ; Saito, Hirohisa ; Yaegashi, Nobuo ; Hashimoto, Koichi ; Mori, Chisato ; Itoh, Shuichi ; Yamagata, Zentaro ; Inadera, Hidekuni ; Kamijima, Michihiro ; Nakayama, Takeo ; Iso, Hiroyasu ; Shima, Masayuki ; Hirooka, Yasuaki ; Suganuma, Narufumi ; Kusuhara, Koichi ; Katoh, Takahiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
著者名 Sata, Fumihiro
e-Rad_Researcher 80157776 著者名 Murata, Katsuyuki
e-Rad_Researcher 70360906 著者名 Saijo, Yasuaki
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 50733367 著者名 Minatoya, Machiko
e-Rad_Researcher 60732120 著者名 Yamazaki, Keiko
e-Rad_Researcher 90752907 著者名 Ait Bamai, Yu
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
著者名 Kawamoto, Toshihiro
著者名 Saito, Hirohisa
著者名 Yaegashi, Nobuo
著者名 Hashimoto, Koichi
著者名 Mori, Chisato
著者名 Itoh, Shuichi
著者名 Yamagata, Zentaro
著者名 Inadera, Hidekuni
著者名 Kamijima, Michihiro
著者名 Nakayama, Takeo
著者名 Iso, Hiroyasu
著者名 Shima, Masayuki
著者名 Hirooka, Yasuaki
著者名 Suganuma, Narufumi
著者名 Kusuhara, Koichi
著者名 Katoh, Takahiko
言語	英語
キーワード	birthweight
	caffeine
	pregnancy
	preterm birth
	small for gestational age
	the Japan Environment and Children's Study
発行日	2019-05
出版者	John Wiley & Sons
収録物名	Paediatric and Perinatal Epidemiology
巻(号)	33(3)
ページ	185-194
抄録	Background: Few previous studies have investigated the association between prenatal caffeine intake and birth size (small-for-gestational-age (SGA), preterm birth, and birthweight Z-score) in Japan. Objectives: We examined the dose-dependency of this association (prenatal caffeine consumption and birth size) as part of the Japan Environment and Children’s Study. Methods: A prospective birth cohort included 94,876 fetuses in Japan. Participants were enrolled between January 2011 and March 2014. Adjusted multiple linear regression and Cox regression models were used to examine the association between prenatal caffeine levels and infant birth size. Results: The median estimated caffeine consumption during pregnancy was 125.5 mg/day, as determined by self-administered questionnaires. There were 7,252 SGA infants (7.6%) and 4,281 preterm birth infants (4.5%). Compared with infants of mothers whose caffeine consumption during pregnancy was in the lowest quartile (4.2 to <86.4 mg/day), infants of mothers whose caffeine consumption was in the highest quartile 4 (205.5 to 5,080.0 mg/day) were at an increased risk of SGA (relative risk [RR]: 1.18; 95% confidence interval [CI]: 1.10, 1.27), and at an increased risk of preterm birth at the 2nd trimester of gestation (RR: 1.94; 95% CI: 1.12, 3.37), with a 0.32-day reduction in gestational age (95% CI: -0.52, -0.12) and with a 0.07 reduction in birthweight Z-score observed (95% CI: -0.09, -0.05). Conclusions: Prenatal caffeine consumption was associated with birth size. However, as the association between prenatal caffeine consumption and birth size was likely 5 confounded by unpredicted potential factors, our confidence in the true causality of the association is moderate.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Dose‐dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study: Paediatric and perinatal epidemiology: 33(3), 185-194, 2019, which has been published in final form at https://doi.org/10.1111/ppe.12551. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
PISSN	0269-5022
EISSN	1365-3016
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1111/ppe.12551