Genetic and Biological Diversity of Porcine Sapeloviruses Prevailing in Zambia

Harima, Hayato; Kajihara, Masahiro; Simulundu, Edgar; Bwalya, Eugene; Qiu, Yongjin; Isono, Mao; Okuya, Kosuke; Gonzalez, Gabriel; Yamagishi, Junya; Hang'ombe, Bernard M.; Sawa, Hirofumi; Mweene, Aaron S.; Takada, Ayato

Genetic and Biological Diversity of Porcine Sapeloviruses Prevailing in Zambia

Harima, Hayato; Kajihara, Masahiro; Simulundu, Edgar et al.

Viruses-Basel, 2020, 12(2), 180

Permalink : https://hdl.handle.net/2115/78074

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アクセス権	open access
URI	https://hdl.handle.net/2115/78074
タイトル	Genetic and Biological Diversity of Porcine Sapeloviruses Prevailing in Zambia
著者	Harima, Hayato ; Kajihara, Masahiro ; Simulundu, Edgar ; Bwalya, Eugene ; Qiu, Yongjin ; Isono, Mao ; Okuya, Kosuke ; Gonzalez, Gabriel ; Yamagishi, Junya ; Hang'ombe, Bernard M. ; Sawa, Hirofumi ; Mweene, Aaron S. ; Takada, Ayato
著者名 Harima, Hayato
著者名 Kajihara, Masahiro
著者名 Simulundu, Edgar
著者名 Bwalya, Eugene
著者名 Qiu, Yongjin
著者名 Isono, Mao
著者名 Okuya, Kosuke
著者名 Gonzalez, Gabriel
著者名 Yamagishi, Junya
著者名 Hang'ombe, Bernard M.
著者名 Sawa, Hirofumi
著者名 Mweene, Aaron S.
e-Rad_Researcher 10292062 著者名 Takada, Ayato
言語	英語
キーワード	porcine sapelovirus
	prevalence
	complete genome
	characterization
	recombination
	Zambia
発行日	2020-02
出版者	MDPI
収録物名	Viruses-Basel
巻(号)	12(2)
ページ	180
抄録	Porcine sapelovirus (PSV) has been detected worldwide in pig populations. Although PSV causes various symptoms such as encephalomyelitis, diarrhea, and pneumonia in pigs, the economic impact of PSV infection remains to be determined. However, information on the distribution and genetic diversity of PSV is quite limited, particularly in Africa. In this study, we investigated the prevalence of PSV infection in Zambia and characterized the isolated PSVs genetically and biologically. We screened 147 fecal samples collected in 2018 and found that the prevalences of PSV infection in suckling pigs and fattening pigs were high (36.2% and 94.0%, respectively). Phylogenetic analyses revealed that the Zambian PSVs were divided into three different lineages (Lineages 1-3) in the clade consisting of Chinese strains. The Zambian PSVs belonging to Lineages 2 and 3 replicated more efficiently than those belonging to Lineage 1 in Vero E6 and BHK cells. Bioinformatic analyses revealed that genetic recombination events had occurred and the recombination breakpoints were located in the L and 2A genes. Our results indicated that at least two biologically distinct PSVs could be circulating in the Zambian pig population and that genetic recombination played a role in the evolution of PSVs.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1999-4915
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/v12020180