Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids

Yamamura, Ryodai; Nakamura, Koshi; Kitada, Naoya; Aizawa, Tomoyasu; Shimizu, Yu; Nakamura, Kiminori; Ayabe, Tokiyoshi; Kimura, Takashi; Tamakoshi, Akiko

Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids

Yamamura, Ryodai; Nakamura, Koshi; Kitada, Naoya et al.

Bioscience of Microbiota,Food And Health, 2020, 39(1), 11-17

Permalink : https://hdl.handle.net/2115/78193

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https://doi.org/10.12938/bmfh.19-010			14

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/78193
タイトル	Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids
著者	Yamamura, Ryodai ; Nakamura, Koshi ; Kitada, Naoya ; Aizawa, Tomoyasu ; Shimizu, Yu ; Nakamura, Kiminori ; Ayabe, Tokiyoshi ; Kimura, Takashi ; Tamakoshi, Akiko
著者名 Yamamura, Ryodai
e-Rad_Researcher 80422898 著者名 Nakamura, Koshi
著者名 Kitada, Naoya
e-Rad_Researcher 40333596 著者名 Aizawa, Tomoyasu
著者名 Shimizu, Yu
e-Rad_Researcher 80381276 著者名 Nakamura, Kiminori
e-Rad_Researcher 90301019 著者名 Ayabe, Tokiyoshi
著者名 Kimura, Takashi
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
言語	英語
キーワード	gut microbiota
	fecal short-chain fatty acids
	serum short-chain fatty acids
	dietary intake
	human
発行日	2020
出版者	BMFH Press
収録物名	Bioscience of Microbiota,Food And Health
巻(号)	39(1)
ページ	11-17
抄録	In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary intake, blood SCFAs, and fecal SCFAs remain uncertain. To clarify these relationships, we collected fecal samples, blood samples, and dietary habit data from 12 healthy adults aged 22-51 years. The relative abundance of several SCFA-producing bacteria, gut microbiota diversity, and functional pathways related to SCFA biosynthesis were positively associated with fecal SCFAs even after adjusting for age and sex. Furthermore, fecal acetate was likely to be positively associated with serum acetate. By contrast, dietary intake was not associated with fecal SCFAs. Overall, the present study highlights the potential usefulness of fecal SCFAs as an indicator of the gut micro biota ecosystem and dynamics of SCFAs in the human body.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	2186-3342
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.12938/bmfh.19-010