open access

https://hdl.handle.net/2115/78214

Concise Synthesis of Potassium Acyltrifluoroborates from Aldehydes through Copper(I)-Catalyzed Borylation/Oxidation

英語

oxidation

2019-05-27

Wiley-Blackwell

Angewandte chemie-international edition

58(22)

7299-7303

Potassium acyltrifluoroborates (KATs) were prepared through copper(I)-catalyzed borylation of aldehydes and subsequent oxidation. This synthetic route is characterized by the wide range of aldehydes accessible, favorable step economy, mild reaction conditions, and tolerance of various functional groups, and it enables the facile generation of a range of KATs, for example, bearing halide, sulfide, acetal, or ester moieties. Moreover, this method was applied to the three-step synthesis of various alpha -amino acid analogues that bear a KAT moiety on the C-terminus by using naturally occurring amino acids as the starting material.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: J. Taguchi, T. Takeuchi, R. Takahashi, F. Masero, H. Ito, Angew. Chem. Int. Ed. 2019, 58, 7299. , which has been published in final form at https://doi.org/10.1002/anie.201901748. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

1433-7851

AA0052535X